They're two of music's best-selling artists with dozens of hit records and millions of fans worldwide.
Though after watching the British documentary Public Enemies – Jay-Z vs Kanye on Channel 4 on Monday night, fans took to Twitter to accuse New York rapper Jay-Z of 'using' his former protegee.
The Channel 4 film followed followed the friendship turned feud between hip-hop's brightest stars, which left viewers divided on their allegiance.
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Public Enemies: A Channel 4 documentary on the friendship and feud between two of hip-hop's greatest names in Kanye West (pictured in 2011) and Jay-Z divided viewers on Monday night as many felt Kanye was bullied by his mentor, New York's Jay-Z
And after gaining an insight into the backgrounds of music royalty, viewers overwhelmingly appeared to be sympathetic to the Chicago rapper ahead of Jay-Z.
Billed as an exposé of their turbulent relationship, the TV show asked childhood friends to a glimpse into what both men were like growing up.
In one such scene, Kanye's childhood friend Eugene McNair showed audiences the rapper's bedroom where they all used to record tracks together.
Opening the door to a messy room, still littered with musical equipment and posters of famous rappers, Eugene explained what the 'lab' was like during those formative musical years.
'Using' Kanye: After gaining an insight into the backgrounds of music royalty, viewers overwhelmingly appeared to be sympathetic to Chicago rapper Kanye ahead of Jay-Z
'We went to his crib, he had all this African s*** throughout the house, he had crates of records everywhere, he had an extensive porno collection, he had fresh clothes.'
There was no disputing that the duo were destined for greatness, but it was Jay-Z who acted in a mentor role to get Kanye to the top.
Some viewers argued that producer turned rapper Kanye was the more talented of the two, with one viewer posting: 'Kayne over Jay-Z, the man is a genius.'
Another, Tammy Cuff, said: 'I love both Jay-Z and Kanye for different reasons - but College Dropout [Kanye's debut album] is perfection and Jay-Z came across as a user.'
The 'user' theme was repeated often by frustrated Twitter fans, with one person even suggesting Jay-Z bullied his 'little brother' Kanye.
Meanwhile, another user pointed out that as a producer, Kanye was responsible for some of Jay-Z's biggest hits.
Twitter reaction: Some viewers argued that producer turned rapper Kanye was the more talented of the two
Friendship turned sour: Meanwhile another user pointed out that as a producer, Kanye West was responsible for some of Jay-Z's biggest hits (pictured here together in 2012)
Despite the sympathy towards Kanye, some in turn went on the defensive of Jay-Z, dubbing the New York man's maneuverings 'just business'.
One user, directly referring to Kanye, said: 'Kanye I love you bro but you are venting at the wrong person. Jay-Z gave you the formula and you lost it.'
Another, tellingly, said: 'To be honest, Jay-Z using Kanye is just business.'
Chrome Hitz continued the defense of Jay-Z by suggesting that without the New York rapper's help there would be no Kanye West.
Richie Yemie seconded this posting: 'You know Jay-Z is one of the major reasons Kanye West made it right?'
In Jay-Z's defense: Despite the sympathy towards Kanye, some in turn went on the defensive for Jay-Z, dubbing the New York man's maneuverings 'just business'