A girl with eczema so severe it kept her awake all night has seen a dramatic recovery after taking a chemotherapy drug.
Honor Stanmore was left so exhausted she couldn't go to school and had to give up dance and swimming classes due to her chronic skin condition.
The nine-year-old's dry, raw skin left her with blood-stained sheets and in so much pain she even struggled to eat.
But Hope's skin has cleared up after taking part in an NHS research trial at Oxford's Churchill Hospital.
She was given methotrexate, a drug commonly used to treat patients battling neck, lung and breast cancer.
Honor Stanmore's eczema was so severe it kept her up all night scratching and unable to eat food
The girl was so exhausted she stopped going to school and her dry, raw skin left her with blood-stained sheets
Her mother Laura Klee, 36, said: 'She was so bad that she couldn't eat because she had eczema all around her mouth, so it was very painful to stretch her mouth open and foods like tomatoes would sting.
'That's when I thought, "Right, this isn't good". It wasn't just hobbies and schooling that was being affected, it was her basic levels of living that she wasn't able to do without any discomfort.
'She itched from the minute she woke up to the minute she went to sleep and became depressed.'
Honor, from Witney, Oxfordshire, was diagnosed with eczema at just four weeks old.
It was treated with steroid creams until 2016, when her eczema got more severe and started to affect her daily life.
Eczema makes the skin itchy, red, dry and cracked, but scratching can make it worse, potentially disrupting sleep and causing bleeding and infections.
Honor's skin has now cleared up after she was prescribed methotrexate, a drug used to treat neck, lung and breast cancers (pictured after the treatment)
Ms Klee, a home support worker for Age UK, added: 'The lack of sleep had been the biggest killer.
'She had broken nights from when she was a baby right up until she was seven.
'The bedsheets used to be covered in blood in the morning from where she had been scratching all night.
'Some nights she'd be screaming and pleading for me to help her, so I'd end up giving her bath or taking her on a drive at 3am just to distract her from itching.
'She still gets anxiety and stomach aches at night time because she associates it with really long, horrible nights where she was awake for hours itching.'
Her mother Laura Klee (pictured together) signed Honor up to take part in a clinical trial at Oxford's Churchill Hospital
Honor, from Witney, Oxfordshire, has been battling the chronic skin condition since she was just four weeks old
The immune system is important in fighting infections, but sometimes it becomes over-active and cause long-term inflammation.
People with
