Cancer patients in the UK will test drug to reduce weight loss and fatigue ...

Drug that could reduce devastating weight loss and fatigue in cancer patients will be tested in £1m trial The drug, known as bermekimab, has been hailed as 'radical' by experts It blocks a molecule which causes inflammation and pain, its developer says  Patients with lung, pancreatic and ovarian cancer will be among the first to try it

By Vanessa Chalmers Health Reporter For Mailonline

Published: 17:17 BST, 10 July 2019 | Updated: 17:17 BST, 10 July 2019

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Cancer patients in the UK will test a drug that has been designed to reduce weight loss and fatigue caused by the disease.

Researchers have been given almost £1million to run a trial in the hopes the drug will ease symptoms which can make life unbearable for people with advanced cancer.

Bermekimab is a form of immunotherapy that blocks a molecule in the body which can cause inflammation and pain, and is believed to be involved in disease progression.

Described as 'radical' by experts, bermekimab has already been fast-tracked for clinical trials in patients with advanced bowel cancer. 

Cancer patients in the UK will test a drug that has been designed to reduce weight loss and fatigue caused by the disease as it progresses in a trial with the University of Edinburgh (stock image)

Cancer patients in the UK will test a drug that has been designed to reduce weight loss and fatigue caused by the disease as it progresses in a trial with the University of Edinburgh (stock image)

Researchers led by the University of Edinburgh will begin recruiting patients from Scotland, Cardiff and London for the study this year.

The team are working with the US-based biotechnology company XBiotech, which developed the therapy. 

Patients with advanced lung, pancreatic or ovarian cancer will be given the first chance to test bermekimab.

As cancer advances, it can hijack the immune system causing life-altering physical symptoms for patients. 

These include loss of appetite and weight loss, muscle loss and fatigue, pain and nausea which can make daily life difficult. 

Bermekimab targets a molecule of the immune system called IL-1alpha, part of the interleukin-1 (IL-1) family of cytokines.

Cytokines are a group of proteins in the body that play an important part in regulating the immune system and its responses, which include inflammation. 

Scientists are working to create IL-1alpha inhibitors to interrupt inflammation processes and treat diseases. 

Dr Barry Laird, senior lecturer in palliative medicine at the University of Edinburgh's Institute of Genetics, is leading the trial. 

He said: 'Using immunotherapy to target the cause of symptoms in cancer is a new approach. 

'If successful, it has the potential to improve quality of life for people with advanced cancer.' 

The trial has been developed in conjunction with the UK's National Cancer Research Institute and the National Institute for Health Research (NIHR).

It offers 'new hope' for patients with advanced cancer, said Dr Steve Wootton, a nutrition expert at the University of Southampton. 

Dr Wootton added the study will allow scientists to test theories about how cancer leads to severe malnutrition and weight loss.

Professor Sam Ahmedzai, from the National Cancer Research Institute's Supportive Care Clinical Studies Group,

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