Monday 6 June 2022 10:19 PM Gut Health Guru DR MEGAN ROSSI: What you can eat to help beat hot flushes trends now
While it’s obvious that gut symptoms are linked to the health of our gut, what people are often surprised to learn is how much else is related to our gut — from immunity and heart health to mental wellbeing.
And add hormones to that list, because yet another role for our all-powerful gut is that it can make and regulate hormones, including our sex hormones.
So it figures that looking after your gut health could help a range of problems related to women’s reproductive cycles, from polycystic ovaries to menopausal symptoms.
And now, we’ve finally got the scientific evidence that backs up what I’ve been seeing in clinic for years: better gut health tends to reduce hormonal distress.
Nor is this just something that affects women. It is known, for instance, that some men with depression have lower testosterone levels. Now, in a study published a few weeks ago, scientists in China have identified a potential cause — a type of gut bacteria that can ‘degrade’ testosterone.
While it’s obvious that gut symptoms are linked to the health of our gut, what people are often surprised to learn is how much else is related to our gut — from immunity and heart health to mental wellbeing, writes Dr Megan Rossi (pictured)
In the study, it was found men with depression had higher levels of this bacteria, and when the scientists from Wuhan University introduced this bacteria to rats, their testosterone levels dropped and they showed depression-like behaviour.
Other animal studies have highlighted the role of gut microbiota (the bacteria, viruses and other micro-organisms found in the gut) in an even more fundamental way. Mice bred to be microbe-free have abnormal sexual development — essentially, the male mice become feminised, and vice-versa.
This is because they lacked the gut microbiota to produce and help regulate their hormones.
And it’s not just about our gut microbiota: vaginal microbiota are also being studied for their role in premature birth.
In fact, my colleagues at King’s College London published a study last year showing that the vaginal microbiome could predict premature births as early as ten weeks into a pregnancy.
(It also goes the other way, with hormones affecting our gut — and many women experience this every month. If you’ve ever felt bloated and find your stools are looser at this time, this is due to the changes in hormones, but more on this another day.)
So what’s going on? First and foremost, our gut microbiome affects the amount of oestrogen circulating in our bloodstream. This is something that relates to men, too, who also produce oestrogen, but in smaller amounts.
The key is beta-glucuronidase, an enzyme produced by certain gut bacteria that ‘recycles’ inactive or used oestrogen and gets it back into the circulation. These oestrogen-controlling gut bacteria even have their own name, the estrobolome.
For now, I’d hold off on probiotic supplements and, instead, think about including these science-backed foods to nourish that all important gut-hormone axis
If there’s an imbalance in the gut microbiota, it can affect the amount of oestrogen in the bloodstream, so you might end up with too much or too little.
For instance, we know that antibiotics not only kill the bad bacteria, they also harm the beneficial ones, including the estrobolome. Indeed, certain antibiotics that are poorly absorbed in the gut, such as ampicillin, can increase the amount of oestrogen excreted manyfold.
An imbalance in gut bacteria is thought to play a role in a range of hormonal conditions ranging from endometriosis and infertility to breast cancer.
In fact some treatments, such as metformin for polycystic ovary syndrome, are thought to work at least in part by targeting and ‘re-balancing’ the gut microbiota. In men, excess oestrogen is linked to gynecomastia (excess breast tissue) and erectile dysfunction, among other symptoms.
Similarly, a healthy gut microbiota is more likely
