Monday 26 September 2022 03:53 PM Statins 'could treat prostate cancer': Drugs starve stubborn tumours, trial ... trends now

Monday 26 September 2022 03:53 PM Statins 'could treat prostate cancer': Drugs starve stubborn tumours, trial ... trends now
Monday 26 September 2022 03:53 PM Statins 'could treat prostate cancer': Drugs starve stubborn tumours, trial ... trends now

Monday 26 September 2022 03:53 PM Statins 'could treat prostate cancer': Drugs starve stubborn tumours, trial ... trends now

Statins 'could treat prostate cancer': Cholesterol-busting drugs starve stubborn tumours, first of its kind trial finds 11 out of 12 prostate cancer patients saw their tumour growth slow after statins This indicated they were seeing 'disease stabilisation', the researchers say Drugs could be offered to patients 'very quickly' if further studies show effect

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Statins could help thousands of men battling stubborn prostate cancer, research suggested today.

The cholesterol-busting pills were shown to starve tumours in a 'first of its kind' trial. 

All but one of 12 patients given the medication saw a clear benefit, the results revealed. 

Charities called the findings 'encouraging', given the drugs are cheap and proven to be safe.

Lead author Professor Hing Leung, from the Cancer Research UK Beatson Institute in Glasgow, said further trials were needed. 

But he added: 'We could use these already-approved medicines very quickly to offer patients better options for treatment.'

Statins could help slow tumour growth in prostate cancer patients that have stopped responding to traditional treatment, a 'first of its kind' trial shows

Statins could help slow tumour growth in prostate cancer patients that have stopped responding to traditional treatment, a 'first of its kind' trial shows

The history of statins

1976

Japanese biochemist Akira Endo isolates mevastatin — the first statin drug — from a fungus.

Animal trials showed the drug lowered cholesterol in dogs, rabbits and monkeys.

However, the drug was never marketed after rat trials showed it could be toxic.

1978

Alfred Alberts discovered lovastatin while working at Merck Research Laboratories.

It was also discovered independently by Dr Endo for the Sankyo company within a year. 

Merck began clinical trials in 1980, but were paused after Sankyo tests of the chemically similar mevastatin found it was toxic in animals.

But trials on lovastatin found no similar issues and in 1983 clinical development was restarted by Merck. 

1987 

Lovastatin becomes the first statin to be approved by the US Food and Drug Administration (FDA).

It reached sales of more than $1billion (£858million) in its first year.

1997 

Atorvastatin is approved. It is sold by Pfizer as Lipitor and is the most popular statin in use today.

It followed the approvals of pravastatin in 1991 and fluvastatin in 1994.

2012

FDA introduces safety warnings on statins stating a small increased risk of higher blood sugar levels and type 2 diabetes diagnosis. 

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Around 52,000 men in the UK and 1650,000 in the US are diagnosed with prostate cancer every year. 

It is usually treated with a combination of radiotherapy and hormone therapy, where levels of testosterone are lowered in the body to slow the growth of the tumour.

Prostate cancer needs androgens, like testosterone, to grow. 

They are made from cholesterol in the blood stream and are produced by the testicles.

But the disease becomes resistant to hormone therapy in up to 20 per cent of cases. This is known as castration-resistant

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