Scientists crack aging mystery: Gene length is the deciding factor trends now
Scientists believe they've cracked the secret of aging.
A major genetic analysis of people, rodents and fish found the length of their DNA was directly linked to their biological age.
Shorter genes were linked to shorter lifespans, while longer genes were linked to better health and longevity.
Scientists believe if they can hijack this mechanism, it could pave the way for a fountain of youth drugs that could slow — or even reverse — aging.
Dr Thomas Stoeger, lead author of the study from Northwestern University in Illinois, said: 'I find it very elegant that a single, relatively concise principle seems to account for nearly all of the changes in the activity of genes that happen in animals as they age.'
Scientists said having longer genes can lead someone to live longer (stock photo)
The length of a gene is based on the number of nucleotides within it. Each string of nucleotides translates to an amino acid, forming a protein.
Therefore a very long gene yields a large protein, and a short gene yields a small protein. A cell needs to have a balanced number of small and large proteins to achieve homeostasis, and problems occur when that balance gets out of whack.
In the study, researchers looked at genetic data from several large datasets, including the Genotype-Tissue Expression Project, a National Institutes of Health-funded tissue bank that archives samples from human donors for research purposes.
The research team first analyzed tissue samples from mice, rats and killifish of various ages.
In all animals, the researchers noticed subtle changes to thousands of different genes across samples.
This means that not just a small subset of genes that contributes to aging. Aging, instead, is characterized by systems-level changes.
This view differs from prevailing biological approaches that study the effects of single genes.
Since the onset of modern genetics in the early 20th century, many
