Would YOU take pills made from someone else's poop to cure a nasty gut ... trends now

Would YOU take pills made from someone else's poop to cure a nasty gut ... trends now
Would YOU take pills made from someone else's poop to cure a nasty gut ... trends now

Would YOU take pills made from someone else's poop to cure a nasty gut ... trends now

How would you react if your doctor told you the best way to get well would be to swallow capsules made from a stranger’s poo?

This was the suggestion made to Carol Goble recently after she contracted Clostridium difficile (C. diff), a bowel infection that can cause recurrent bouts of severe diarrhoea.

So severe was her infection that for almost nine months she could never be more than a few feet away from a loo.

‘It was no life at all — I stopped going out,’ recalls Carol, 76, a retired secretary from South London. Trying to cut down on trips to the loo, she also stopped eating and drank only water.

How would you react if your doctor told you the best way to get well would be to swallow capsules made from a stranger’s poo?

This was the suggestion made to Carol Goble recently after she contracted Clostridium difficile (C. diff), a bowel infection that can cause recurrent bouts of severe diarrhoea. So severe was her infection that for almost nine months she could never be more than a few feet away from a loo

This was the suggestion made to Carol Goble recently after she contracted Clostridium difficile (C. diff), a bowel infection that can cause recurrent bouts of severe diarrhoea. So severe was her infection that for almost nine months she could never be more than a few feet away from a loo

‘My only “meal” each day became a sachet of Complan [a meal replacement drink] in the evening,’ she says. In four months, she lost 3st in weight, dropping from a size 18 to a 12, and felt constantly lacking in energy.

The C. diff bacterium is commonly found in the intestines of very young children (though they are normally only carriers) and people over 65, but usually it doesn’t cause problems.

But taking antibiotics can disturb the natural balance of the trillions of microbes that make up our gut microbiome, allowing C. diff to multiply. The bacterium produces toxins that irritate the bowel lining, leading to symptoms including diarrhoea, stomach cramps, fever and nausea.

C. diff, which can be spread by poor hand washing, for instance, is a particular risk for people who have been taking antibiotics; but older people in hospitals or care homes or those with a compromised immune system are especially vulnerable (regardless of whether they’ve taken antibiotics).

For stubborn infections, standard treatment is with antibiotics — but a new approach, previously reported in Good Health, is to treat the patient with a faecal microbiota transplantation (FMT), where healthy bacteria is taken from the stool of a suitable donor.

Taking antibiotics can disturb the natural balance of the trillions of microbes that make up our gut microbiome, allowing C. diff to multiply

Taking antibiotics can disturb the natural balance of the trillions of microbes that make up our gut microbiome, allowing C. diff to multiply

The stool is processed before being transferred to the intestine of a patient via a nasal tube into their stomach or into the colon via the rectum. It can also be transferred less invasively via oral capsules — as in Carol’s case — and swallowed like normal pills.

Now FMT has been approved by the health regulator NICE (the National Institute for Health and Care Excellence) for patients who have suffered at least two recurrent C. diff infection episodes which haven’t responded to antibiotics.

The decision was made after clinical trials involving 274 patients at hospitals in Italy, Denmark, the Netherlands and Canada showed that FMT can clear up to 94 per cent of infections. NICE estimates that around 500 of the estimated 13,000 annual UK cases of C. diff could be treated by FMT in future.

One of the studies on which it based its decision, published in the New England Journal of Medicine in 2013, found that after just a single infusion, 81 per cent of patients no longer experienced diarrhoea, compared with 31 per cent of a control group who received the antibiotic vancomycin, a standard treatment for C. diff.

It is thought FMT works by inhibiting the growth of C. diff and increasing diversity in the microbiome, rather than by killing C. diff itself.

The treatment has been offered since 2015 to around 250 patients at Guy’s and St Thomas’ Hospital NHS Foundation Trust, London.

‘A lot of antibiotics damage our gut microbiome significantly, and for prolonged periods,’ says Dr Simon Goldenberg, a consultant microbiologist and infection control doctor at the Trust.

The stool is processed before being transferred to the intestine of a patient via a nasal tube into their stomach or into the colon via the rectum. It can also be transferred less invasively via oral capsules ¿ as in Carol¿s case ¿ and swallowed like normal pills

The stool is processed before being transferred to the intestine of a patient via a nasal tube into their stomach or into the colon via the rectum. It can also be transferred less invasively via oral capsules — as in Carol’s case — and swallowed like normal pills

‘It can take several months for the microbiome to come back to the same level of diversity, making us more susceptible to infections such as C. diff. Because many of the broad-spectrum antibiotics decimate the good bacteria, it creates a niche allowing the C. diff to get into the gastrointestinal tract (the passageway of our digestive system) and thrive. This bacterium grows and starts secreting toxins.’

While antibiotics remain the first-line treatment and are effective in 80 per cent of cases, the remainder need a second course — but 40 per cent still won’t respond to this.

‘Some patients remain on antibiotics on and off for many years, which can have some unpleasant side-effects, such as nausea and vomiting, and affect taste,’ says Dr Goldenberg.

‘Patients with C. diff can become dehydrated as a result

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