Canola oil has been heavily marketed as a healthy choice because it is low in saturated fat.
But a new study suggests the trendy kitchen staple could worsen memory loss and learning ability in Alzheimer's patients.
It may also increase the build-up of plaques in the brain, a hallmark of the degenerative disease.
And despite its seemingly wholesome profile, researchers discovered it caused weight gain.
The findings suggest for the first time that long-term consumption of canola oil is not beneficial to brain health.
A new study suggests canola oil worsens memory loss and learning ability in Alzheimer's patients (stock image)
'Canola oil is appealing because it is less expensive than other vegetable oils, and it is advertised as being healthy,' said senior study investigator Professor Domenico Praticò, director of the Alzheimer's Center at Lewis Katz School of Medicine at Temple University (LKSOM) in Philadelphia.
'Very few studies, however, have examined that claim, especially in terms of the brain.'
How the research was carried out
Dr Praticò and his colleague Lauretti had previously investigated the effects of extra-virgin olive oil on brain health on mice.
In that study, they found that rodents genetically modified to have Alzheimer's that were fed a diet enriched with olive oil displayed memory improvement.
They also had reduced levels of amyloid plaques and phosphorylated tau – these are responsible for the formation of neurofibrillary tangles, the prime suspects in cell death and tissue loss in the Alzheimer brain.
For their latest work, they wanted to determine whether canola oil is similarly beneficial for the brain.
The animal model was designed to mimic Alzheimer's in humans, progressing from an asymptomatic phase in early life to full-blown disease in aged rodents.
The mice were divided into two groups at six months of age, before they developed signs of Alzheimer's. One group was fed a normal diet, while the other was fed a diet supplemented with the equivalent of about two tablespoons of canola oil daily.
After 12 months, they were assessed. One of the first differences observed was in body weight – animals on the canola oil-enriched diet weighed significantly more than mice on the regular diet.
Through maze tests, the team noticed mice that had consumed canola oil suffered impairments in working memory.
Examination of brain tissue from the two groups of mice revealed that canola oil-treated animals had greatly reduced levels of amyloid beta 1-40, a peptide which protects neurons from damage.
They also showed increased formation of amyloid plaques in the brain.