When Tottenham and Arsenal meet, there's guaranteed to be plenty riding on the outcome regardless of their respective positions in the league table.
But Saturday lunchtime's clash at Wembley will genuinely have a major impact on the race to finish in the Premier League top four.
If Arsenal complete the double over their North London rivals, they will move within a point of Spurs in third place, a scenario that seemed unthinkable just a few weeks ago.
We take a look at some of the key questions ahead of what will doubtless be a tasty encounter.
Mauricio Pochettino and Unai Emery are set to go head to head as Tottenham host Arsenal
Spurs will move within a point of their north London rivals if they claim victory at Wembley
Can Tottenham's title aspirations be resurrected?
Back-to-back losses to Burnley and Chelsea this week have made it incredibly difficult for Mauricio Pochettino's side to claim the title from here.
With 10 matches remaining, they trail leaders Liverpool by nine points and second-placed Manchester City by eight. While Liverpool have lost once in the league this season and City four times, Spurs have now lost eight times.
The one small glimmer of hope for Spurs is that they still have to travel to Liverpool on March 31 and City on April 20.
Tottenham suffered a shock 2-1 defeat at Burnley last Saturday in a blow to their title hopes
But after this week's damaging results, even victories in those two matches are likely to be insufficient. Besides, Spurs would have to be flawless in all their other matches as well.
And while both Liverpool and City continue to pick up the results they need, Spurs are just so inconsistent and unpredictable it's incredibly unlikely they could take maximum returns from here.
Having been within five points of the top two at the start of February, Spurs have fallen away disappointingly.
Spurs then lost to their London rivals Chelsea on Wednesday night to drop further off the pace
March 3 Everton (A)
March 10 Burnley (H)
March 17 Fulham (A)
March 31 Tottenham Hotspur (H)
April 5 Southampton (A)
April 14 Chelsea (H)
April 21 Cardiff City (A)
April 26 Huddersfield (H)
May 4 Newcastle United (A)
May 12 Wolves (H)
March 2 Bournemouth (A)
March 9 Watford (H)
March 30 Fulham (A)
April 6 Cardiff City (H)
April 14 Crystal Palace (A)
April 20 Tottenham (H)
April 24 Man United (A)
April 28 Burnley (A)
May 4 Leicester City (H)
May 12 Brighton (A)
March 2 Arsenal (H)
March 9 Southampton (A)
March 31 Liverpool (A)
April 7 Brighton H
April 13 Huddersfield (H)
April 20 Manchester City (A)
April 27 West Ham (H)
May 4 Bournemouth (A)
May 12 Everton (H)
Can Arsenal finish above their rivals?
Of course, it used to so commonplace that Arsenal would finish ahead of their north London rivals in the table their fans invented the movable feast of St Totteringham's Day to celebrate their supremacy.
But the last few years have seen the tables turned and it looked highly likely a month ago that Spurs would finish ahead of Arsenal by a double digit points margin.
Indeed, 10 points split Spurs in third from Arsenal in fifth on February 10. But Tottenham's collapse in form has coincided with a run of five wins in six league games for the Gunners to close that gap to four points.
Arsenal have won five of their last six Premier League matches ahead of Saturday's derby
If they win at Wembley, they'll move within a single point and could well finish ahead of Spurs for the first time since 2015-16.
That really would represent a satisfying achievement in Unai Emery's first season at the Emirates Stadium.
One good omen for Spurs is that they haven't lost three consecutive Premier League games since November 2012, so slumps of this nature are unusual. The bad news is that third defeat seven years ago came against Arsenal.
It's still possible that Unai Emery's Arsenal could finish above Spurs in his first season in charge
Will Harry Kane return to form?
It's curious to think that Spurs