The north London derby kicks off the latest round of Premier League fixtures with Arsenal looking to carry on their impressive form and Tottenham needing to recover from back-to-back defeats.
It's also derby day on Merseyside where Everton would love to put the brakes on Liverpool's charge at the top of the table.
Manchester City are at Bournemouth, United are at home while Fulham caretaker boss Scott Parker welcomes his former club Chelsea to Craven Cottage and Brendan Rodgers takes charge of Leicester for the first time.
Here's our game-by-game guide to the weekend - kick-offs 3pm Saturday unless stated otherwise.Tottenham v Arsenal - Saturday 12.30pm
Tottenham have already lost one London derby this week as defeat by Chelsea, on the back of a bubble-bursting loss at Burnley, snuffed out any lingering hopes they had of winning the title. They’ve slipped back into the top-four race and Arsenal could move within a point of their close rivals with a win at Wembley. Unai Emery’s side may fancy their chances. They’ve won four of five games since going down 3-1 to Manchester City (they lost to BATE Borisov but went through on aggregate) and the biggest thing to take away from their recent results, capped by the 5-1 hammering of Bournemouth, is that across four wins they’ve had EIGHT different scorers. Spurs have had six in the same period but, for the first time since December 2013, played out a Premier League match without registering a shot on target - at Stamford Bridge on Wednesday night - when Harry Kane’s most notable contribution was a couple of angry exchanges, one of which he could’ve been sent off for. The reverse fixture at the Emirates Stadium finished 4-2 to Arsenal and they are 5/2 to win again. You can get 9/2 they win with both teams scoring while over 3.5 goals in the game looks good at 7/4.
Alexandre Lacazette and Arsenal are in fine form ahead of the north London derby
Harry Kane (right) is back for Tottenham but they've lost both games since his return
Bournemouth’s defeat by Arsenal on Wednesday was expected. City needing a penalty to overcome West Ham was not. However, they got the job done, with just their second 1-0 win of the season, and should do again as they stare down Liverpool in this intriguing battle for the title. City are no better than 1/4 for the points which is about right considering they’ve won seven out of seven Premier League games against Bournemouth, scoring 24 goals for the loss of just three. Ignore City’s run of three defeats in their last three league games on the road as, since the most recent of these - a 2-1 loss at Newcastle at the end of January - they’ve played away from the Etihad Stadium four times, winning at Everton, Newport in the FA Cup and Schalke in the Champions League before beating Chelsea on penalties at Wembley to lift the Carabao Cup. This should be straightforward enough, even without the injured Fernandinho, and they are 15/2 to win 2-0 or 8/1 to win 3-0.
Sergio Aguero was the Man City match-winner again in midweek as they beat West Ham
Huddersfield’s win over Wolves on Tuesday night left Brighton ploughing a lonely furrow. They are now the only one of the 92 clubs in the four top divisions in England still seeking a first league win of 2019. These are testing times indeed for manager Chris Hughton. It’s not exactly been a barrel of laughs for his opposite number on Saturday either but Jan Siewert was a happy man in midweek with his wild celebrations after beating Wolves. He’ll be hoping that rubs off and kickstarts something and at 9/2, against a Seagulls team who even lost to Fulham not too long ago, Huddersfield will have plenty of backers. But a draw (5/2) looks the best bet and you can get 6/1 it finishes 1-1.Burnley v Palace
This is another one where a share of the points looks about right. Burnley’s eight-game unbeaten run came to an end at St James’ Park against a Newcastle side who have found a bit of form at home over the past few games. Burnley too are continuing to get things right in front of their own fans as last week’s surprise win over Spurs took them to four wins and a draw at Turf Moor since losing heavily to Everton on Boxing Day. Palace lost their own unbeaten run in midweek - seven games - against Manchester United but, at the risk of sounding like a broken record, they are better away than they are at home. Any score draw here is 18/5. Ashley Barnes (2/1) and Chris Wood (11/5) jump off the page for anytime scorers as they’ve been responsible for Burnley’s last eight Premier League goals. Both have four in their last five games. You can get 8/1 (bet365) they’re both on target.Man United v Southampton
Manchester United’s injury list is a long one but a fit and firing Romelu Lukaku playing in his preferred position should make sure they don’t miss their crocked stars against Southampton. Lukaku, who looked good against Liverpool last week despite being stuck out wide while the injured Marcus Rashford hobbled around in the middle, took advantage of