Barcelona showed terrific spirit to beat Real Betis last weekend and they are likely to face another tough task when they take on Getafe.
Meanwhile, title rivals and current leaders Real Madrid host struggling Celta Vigo and there are plenty of other intriguing fixtures in the Spanish top flight.
Sportsmail guides you through the best of the action this weekend ahead of another exciting round of fixtures in LaLiga...
Barcelona are set to face another difficult task this weekend as they host third placed Getafe
Barcelona and Lionel Messi are set to face another difficult task as they host Getafe
Barcelona v Getafe (Saturday, 3pm)
Barcelona overcame a scare last weekend as they beat Real Betis 3-2 in an enthralling encounter, and Quique Setien's side know they cannot afford many slip-ups if they are to keep the pressure up on Real Madrid, who are three points ahead of them.
Clement Lenglet is unavailable for Barcelona following his red card against Betis. Meanwhile, the injury to Ousmane Dembele and the continued absence of Luis Suarez places further pressure on Lionel Messi and Antoine Griezmann to score with an emergency signing no closer.
Getafe go into this clash in fine form having won their last four La Liga matches, so this could be a close game.
The experienced Angel Rodriguez, who has scored nine league goals this season and has been heavily linked with a move to the Nou Camp this week, poses an attacking threat for the visitors and will look to get the better of a defence that isn't especially convincing.
Angel Rodriguez has scored nine La Liga goals this season and will pose a threat
Real Madrid v Celta Vigo (Sunday, 8pm)
Real are set to receive a major boost ahead of this game, with Eden Hazard poised to be available for the first time since November after recovering from injury.
Zinedine Zidane's team ran out 4-1 winners against Osasuna despite falling behind and they will be hopeful of getting all three points again.
Celta Vigo, down in 17th, will be determined to show that they are no pushovers, and they did cause a shock by beating Sevilla last weekend.
However, it is still widely expected that Real will be able to prevail as they look to take another step towards securing the title.
Eden Hazard could return to action for Real Madrid when they host Celta Vigo on Sunday
Valencia v Atletico Madrid (Friday, 8pm)
This game gets the latest batch of LaLiga fixtures underway and it is a difficult one to call.