In what appeared a frantic and often desperate pursuit, Tottenham oscillated in and out of negotiations with a number of high-profile figures across Europe, some of whom got the fans excited, others sending social media into a storm of disdain.
The likes of former boss Mauricio Pochettino, Anotnio Conte, Julian Nagelsmann and Erik Ten Hag certainly fall into the former category, with Paulo Fonseca and particularly Gennaro Gattuso at the opposite end of the spectrum.
Nonetheless, the talk is now over, with Nuno signing a two-year deal. The former Wolves boss, who ended a four-year spell with the club at the end of the 2020-21 season, now immediately gets to work, with pre-season set to start on Monday.
There is a quick turnaround following the end of the European Championships, with just 34 days until the new Premier League season gets underway. Tottenham are set to open their campaign with an unenviable fixture at home to Manchester City on Sunday, August 15.Insurance Loans Mortgage Attorney Credit Lawyer
Of course, the transfer window is already open, and Nuno - alongside the newly-appointed director of football Fabio Paratici - will already be scouting for potential signings.
However, his appointment will also have a drastic impact on those already within the squad. Sportsmail analyses Tottenham's five winners and losers after their managerial search finally came to an end.
Tottenham ended their 72-day search for a manger on Wednesday, with the appointment of former Wolves boss Nuno Espirito Santo on a two-year deal
In attempting to understand how those within the squad will be impacted by Nuno's arrival, it's essential to first outline just what the Portuguese manager will bring.
After a violently negative response to their initial participation in the European Super League, and particularly after the somewhat disastrous reign of Mourinho, Daniel Levy issued a statement in May, in which he stressed he was looking to appoint a manager who would share the club's DNA.
The words 'free-flowing, attacking and entertaining' were used, while the emphasis on developing young players was also asserted.
In Nuno, Tottenham have got something closer to Mourinho, who the 47-year-old played under while at Porto.
Typically utilising a 3-4-3 formation, Nuno's Wolves were known for being electric on the counter attack - though less so in a difficult 2020-21 campaign - prioritising defensive stability before an expansive, possession-based style.
Though deflated by the absence of Raul Jimenez and departure of Diogo Jota, Wolves managed just 36 goals last season, however, fewer than Harry Kane's individual involvements of 23 goals and 14 assists.Insurance Loans Mortgage Attorney Credit Lawyer
However, one of Paratici's key reasons for appointing Nuno was his adaptability, noting he utilised a 4-4-2 with Porto and either a 4-3-3 or 4-2-3-1 with Valencia in an interview following the announcement.
Importantly, one of Nuno's biggest strengths is his ability to get the most out of existing players, particularly the youngsters within the squad. Similarly to Pochettino, he also demands the highest levels of fitness, something Tottenham appeared to be lacking last season, with a familiar pattern emerging of conceding late goals.The winners from Nuno's arrival Matt Doherty
Matt Doherty thrived under Nuno at Wolves, earning a £15m move to Tottenham last summer
Now, onto the players that will benefit from Nuno's arrival, and there's one name that immediately stands out - Matt Doherty.
The full-back was simply electric under Nuno, contributing 15 goals and assists across Wolves' first two seasons back in the Premier League.
He arrived at Tottenham last summer in a £15million move, with the fans ecstatic having acquired what was deemed as one of the Premier League's best full-backs.
However, albeit playing largely at right back, rather than as a wing-back, Doherty struggled to make an impact in his debut campaign. He was below Serge Aurier and on occasion Japhet Tanganga in the pecking order, starting just 13 league matches, scoring no goals and providing only two assists.
Doherty has an excellent relationship with Nuno, however, and a return to wing back could see the 29-year-old finally realise his potential at Tottenham.Joe Rodon
Joe Rodon (right) was impressive throughout Wales' Euro 2020 campaign, though he did struggle against Denmark in their 4-0 last-16 defeat
Joe Rodon is another player who Tottenham signed last season, again in a £15mi deal, this time from Championship side Swansea.
The Welshman showed glimpses of promise during his first season, though also showing a few serious lapses in concentration, notably almost handing Chelsea a late winner in a 0-0 draw at Stamford Bridge, with a near-catastrophic error in his debut for the club.
Rodon's opportunities were fairly limited throughout the season, however. He made just 14 appearances in total, having been cup-tied for the Carabao Cup and surprisingly left out of Mourinho's Europa League squad.
With Ryan Mason replacing Mourinho as interim head coach for the final stretch of the season, Rodon again found himself on the periphery of the squad. He was left out in five of the six games he was eligible for and came on for just one minute in Tottenham's final-day win over Leicester.
However, aside from the bitterly disappointing 4-0 defeat to Denmark, Rodon performed well for Wales at Euro 2020 and could find himself busy next season, particularly if Nuno does opt for a three-at-the-back system.Tanguy Ndombele
Tanguy Ndombele (left) fell down the pecking order under interim head coach Ryan Mason
Tanguy Ndombele really is something of an enigma at Tottenham. Recently compared to Ronaldinho by Gareth Bale, the Frenchman clearly has the ability to shine in the Premier League.
However, despite being called upon significantly more by Mourinho last season, the performances still weren't quite to the standard expected, particularly towards the back-end of the campaign.
The midfielder, who missed out on a place in the France squad for this summer's European Championships, was another player who was banished to the sidelines when Mason took over, starting just one of seven games during his tenure.
At just 24-years old, Ndombele will get a fresh start under Nuno. Levy has been instrumental in keeping the Frenchman at the club, after he initially stated his desire to leave following a troublesome first campaign under Mourinho. And having splashed out £65million on the club's record signing, Levy will be keen to see him back in the team once more.