The Gypsy King furthered his status as the heavyweight division's 'top dog', as he put it, as he knocked Wilder down three times to retain his WBC strap in Las Vegas.
Fury was floored twice by a dangerous Wilder, both in the fourth round, with the American providing another reminder of his ferocious punch power, despite falling to a second-straight defeat to the Brit.
Fury serenaded the crowd with a rendition of 'Walking in Vegas' following his emphatic victory, while a battered and bruised Wilder swiftly departed to hospital for precautionary tests.
There are now a number of options ahead for Fury, including WBC mandatory challenger Dillian Whyte, while the win pushed him closer to an undisputed showdown against either Anthony Joshua or his recent conqueror Oleksandr Usyk.
Tyson Fury retained his WBC belt with an 11th-round stoppage win over Deontay Wilder
He discussed his immediate plans alongside trainer SugarHill Steward (left) after the fight
*as per Betfair
Fury was asked about the possibility of fighting for all of the belts in his post-fight press conference, with the 33-year-old insisting he'll now take a break.
'We'll see,' he said. 'I've just earned a well-earned break from everything.
'I've been away from my family for six months, I've been home two weeks out of the last six months.
'Before I start thinking about fighting other men, I'm going to bask in this victory, because tonight was one of my greatest wins.
'I got off the floor to do it and I'm the big dog in the division.
'I'm probably one of the heaviest heavyweight champions in history tonight, 277lbs, and I was fit, strong in there and I felt good.
'We'll see what today brings and tomorrow as well.'