Clyde Edwards-Helaire had begun to establish a bigger role in the Chiefs' offense coming into Sunday night's showdown with the Bills, topping 100 yards on the ground in each of Kansas City's previous two games. But he didn't get a full chance to make it three straight against Buffalo, leaving Week 5's prime-time game with a knee injury. The second-year back saw his leg bend awkwardly on a third-quarter carry and was helped off the field by teammates before exiting to the locker room, where he was quickly ruled out for the remainder of Sunday's contest.
Edwards-Helaire got help from Tyreek Hill and fellow running back Darrel Williams on his way off the field, then received attention in the Chiefs' medical tent before leaving the field. It wasn't long before the team officially ruled him out, suggesting his knee injury might be serious. Further testing is expected to confirm his status, but