Whether you're only competing for the weekly payouts and pride in your NFL office pool picks, or if you're near the top of the standings in your NFL pick'em league, the middle portion of the season is one of the best chances to hone in your NFL pool strategy. Some pretty clear patterns are starting to emerge in the NFL, like the Bills absolutely dominating everybody they've played since a season-opening loss to the Steelers. Buffalo has won four in a row by an average margin of victory of nearly 29 points and three of the four teams it beat were in the playoffs a season ago.
This week, the Bills take on another playoff team from a season ago when they visit the Titans on Monday Night Football. The Bills are only the fifth biggest favorites (Buffalo -5.5) of the week in the latest NFL spreads from Caesars Sportsbook. Should you select the Bills in your NFL pick'em pool? What about in your NFL confidence pool picks? Before you make your NFL predictions, you need to see the Week 6 NFL football pool picks from SportsLine's proven model.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.
More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.
One of the top Week 6 NFL pick'em predictions from the model: The Colts cruise past the Texans for a comfortable 13-point win. The Colts dropped to 1-4 after blowing a 16-point lead to the Ravens on Monday night and the injury situation in Indianapolis is less than ideal after several more defensive starters were hurt in Week 5.
However, the Texans have lost by double-digits in three of the four games since beating the Jaguars in Week 1. Plus, Houston is coming off a heartbreaking loss to the Patriots last week. Houston opened up a 22-9 lead early in the second half only to watch it all crumble as New England stormed back to win 25-22 in the final minute of the game.
Meanwhile, despite the loss on Monday, Carson Wentz and Indianapolis offense have something positive to build from after racking up 513 yards of total offense against the Ravens. Wentz had his best game of the season, going 25-of-35 for 402 yards with two touchdowns and zero interceptions. The model likes the Colts to pile up nearly 400 yards of total offense against the Texans, helping Indianapolis win in over 80 percent of simulations with a projected final score of 30-17.How to make Week 6 NFL office pool picks