The Reds could briefly go top of the table, should they beat the Hornets in the lunch time kick-off on Saturday afternoon.
However, they are likely to miss the Brazilian pair who are still away on international duty and set to face Uruguay at 1.30am British time on Friday morning - just 35 hours before kick-off at Vicarage Road.
Fabinho is on international duty with Brazil who play Uruguay 35 hours before Liverpool kick-off at Watford
Speaking to Brazilian press, Fabinho has admitted he can't see himself or Alisson taking part in the game due to the quick turnaround required to participate.
He also claimed the club are deciding whether they should stay in a hotel in England while they quarantine, or whether they should stay in Spain before the Reds face Atletico Madrid on Tuesday.
The midfielder said: 'I believe that this first match against Watford it will be very hard for us, I don't think we will play. Neither Alisson or myself.
Fabinho says both he and Alisson (pictured) will likely miss the Reds' clash against Watford
'The match against Uruguay will be Friday overnight