Rams vs. Giants odds, line, spread: 2021 NFL picks, Week 6 predictions from proven computer model

Rams vs. Giants odds, line, spread: 2021 NFL picks, Week 6 predictions from proven computer model
Rams vs. Giants odds, line, spread: 2021 NFL picks, Week 6 predictions from proven computer model

The New York Giants will take on the Los Angeles Rams at 1 p.m. ET on Sunday at MetLife Stadium. New York is 1-4 overall and 0-2 at home, while Los Angeles is 4-1 overall and 2-0 on the road. The Giants lost 44-20 to the Cowboys last week. The Rams beat the Seahawks, 26-17. 

The Rams won their last meeting against the Giants on Oct. 4 of last season, 17-9. Los Angeles is favored by eight points in the latest Giants vs. Rams odds from Caesars Sportsbook, and the over-under is set at 48.5. Before entering any Rams vs. Giants picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Giants vs. Rams. You can head to SportsLine to see its picks. Here are several NFL betting lines for Rams vs. Giants:

Giants vs. Rams spread: Rams -8 Giants vs. Rams over-under: 48.5 points

Featured Game | New York Giants vs. Los Angeles Rams

What you need to know about the Giants

Saquon Barkley suffered an ankle injury against the Cowboys and will not play in Week 6. Devontae Booker had a rushing TD and a receiving score against Dallas and will start vs. the Rams. Daniel Jones suffered a concussion, but he has been cleared for Week 6. He is third among QBs with 197 rushing yards so far this season. 

Kadarius Toney set a Giants franchise rookie record with 189 receiving yards on 10 receptions. Sterling Shepard, who last played in Week 3, is set to return from a hamstring injury. Kenny Golladay will not play in Week 6 because of a knee injury. Darius Slayton (hamstring) is questionable. 

What you need to know about the Rams

Robert Woods had 12 receptions for 150 yards in the win over Seattle. It was his seventh career game with 10-plus catches and his fifth career game with 150-plus receiving yards. Cooper Kupp has averaged nine receptions and 108.2 receiving yards in his last six road games. He has five-plus receptions in his last nine games. 

Matthew Stafford has passed for two-plus TDs in four games so far this season. Darrell Henderson has 80-plus scrimmage yards in his last four games. Leonard Floyd has a sack in three of his past four games. 

How to make Rams vs. Giants picks

The model has simulated Giants vs. Rams 10,000 times and the results are in. It is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Giants vs. Rams? And which side of the spread hits well over 50

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