Two division leaders and Super Bowl contenders in the AFC will collide when the Buffalo Bills visit the Tennessee Titans for a key Monday Night Football matchup. The Bills (4-1) have established themselves as the team to beat in the AFC after a decisive 38-20 victory over the Kansas City Chiefs. Buffalo enters Week 6 tied with the Ravens and Chargers for the best record in the conference. Meanwhile, the Titans (3-2) lead the AFC South by two games and are coming off a victory over the winless Jaguars.
Kickoff is set for 8:15 p.m. ET. Buffalo is a six-point favorite in the latest Bills vs. Titans odds from Caesars Sportsbook, and the over-under for total points scored is 53.5. Before you make any Titans vs. Bills picks or Monday Night Football predictions, you need to see what SportsLine senior analyst Larry Hartstein has to say.
A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. This season he has been on fire. Through five weeks Hartstein is 21-7-1 with his NFL picks, for a winning percentage of 75.0 and a profit of $1,305. With his last 26 picks, he is an absurd 21-5.
He also has had a keen eye for the tendencies of the Titans, posting an amazing 20-7-1 record (+1257) on his last 28 against the spread picks involving Tennessee. Anyone who has consistently followed him is way up.
Now, Hartstein has broken down Bills vs. Titans from all angles and just released his coveted best bets. You can head to SportsLine to see his NFL picks. Here are the NFL odds and betting lines for Titans vs. Bills:
Bills vs. Titans spread: Buffalo -6 Bills vs. Titans over-under: 53.5 points Bills vs. Titans money line: Buffalo -270, Tennessee +220 BUF: Bills lead the league in scoring defense (12.8 points per game) TEN: RB Derrick Henry leads the league in rushing yards per game (128.0)Featured Game | Tennessee Titans vs. Buffalo Bills
The Bills lead the league in scoring defense (12.8 points per game) and total defense (251.8 yards per game) and rank second in passing defense (173.4 yards per game). Last week, they limited the high-scoring Chiefs to just 20 points and 392 yards, well below their season averages.
In addition, tight end Dawson Knox has emerged as a legitimate receiving threat. A third-round pick in 2019, Knox has five touchdown catches this season. That's the second most in the NFL and most among tight ends. Knox is second to receiver Stefon Diggs for the most red zone targets (seven) on the team and leads the team in red zone receiving yards (29) and red zone receiving touchdowns (three).
Why the Titans can coverRunning back Derrick Henry has been his usual unstoppable self to start the season. Henry leads the league in rushing yards per game (128.0) and is tied for the league lead in total touchdowns (seven). He is on pace to shatter the NFL's single-season records for rushing yards, rushing attempts and total touches.
In addition, Tennessee dominated Buffalo when these teams met last season. In Week 5 of last year, the Titans forced three turnovers, including two interceptions of Bills quarterback Josh Allen, and converted all of them into touchdowns in a 42-16 win. Tennessee quarterback Ryan Tannehill had an efficient game, completing 21-of-28 passes for 195 yards and three touchdowns.
How to make Bills vs. Titans picksFor Monday Night Football, Hartstein is leaning over on the point total, but he also says a critical X-factor makes one side of the Titans vs. Bills spread a must-back. He's sharing what it is, and which side to back, only at SportsLine.
So who wins Bills vs. Titans on Monday Night Football? And what critical
