Following a drama-filled edition of Monday Night Football in Week 5, another AFC matchup is set for the Week 6 finale. The Tennessee Titans will welcome the Buffalo Bills to Nashville for a face-off between AFC division leaders. Tennessee is 3-2 this season, nudging above the .500 mark after a win last week over the Jacksonville Jaguars. Buffalo leads the NFL in point differential and sits atop the AFC East at 4-1.
Kickoff is at 8:15 p.m. ET in Nashville. Caesars Sportsbook lists the Bills as six-point road favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 53.5 in the latest Bills vs. Titans odds. Before you make any Titans vs. Bills picks or NFL predictions, you need to see what SportsLine's advanced computer simulation model has to say.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Bills vs. Titans, and it just released its coveted picks and predictions. You can head to SportsLine now to see model's Titans vs. Bills picks. Now, here are several NFL odds and betting lines for Bills vs. Titans:
Bills vs. Titans spread: Bills -6 Bills vs. Titans over-under: 53.5 points Bills vs. Titans money line: Bills -270, Titans +220 BUF: Bills are 4-1 against the spread this season TENN: Titans are 3-2 against the spread this seasonFeatured Game | Tennessee Titans vs. Buffalo Bills
The Bills are dynamic in their own right offensively, but the Titans are also struggling on the defensive side of the ball. Tennessee is just No. 24 in scoring defense this season, with the No. 27 mark in net yards per pass attempt allowed, the No. 26 mark in yards per rushing attempt allowed, and the No. 26 mark in turnover creation rate. Buffalo is leading the NFL in scoring offense at 34.4 points per game, and the Bills are scoring points on 34.4 percent of their offensive possessions.
The Bills are a top-eight team in total offense (410.4 yards per game) and rushing offense (702 yards in five games), with the No. 3 mark in third down efficiency at better than 49 percent.
Why Derrick Henry and the Titans can coverTennessee currently ranks No. 8 in the NFL in first downs allowed, with opponents moving the chains only 98 times in five games. The Titans are also above-average in third down efficiency allowed, giving up a conversion on only 37.7 percent of opportunities.
Tennessee's defense also employs a "bend but don't break" model that includes an above-average mark in red zone touchdown prevention. With those metrics joining forces with a top-10 scoring offense and one of the NFL's best running games, the Titans can draw up a formidable game plan against Buffalo at home.
How to make Bills vs. Titans picksSportsLine's model is leaning under on the point total, with no Bills rusher projected to reach 60 yards and the Titans projected to throw for fewer than 200 yards. The model also says one side of the spread hits in well over 60 percent of simulations. You can only get the model's strong Bills vs. Titans picks at SportsLiine.
So who wins Titans vs. Bills on Monday Night Football? And
