The San Francisco 49ers (2-3) and the Indianapolis Colts (2-4) will duel it out in a primetime matchup on Sunday Night Football. The Colts have won two of their last three games and are currently second in the AFC South. San Francisco, meanwhile, looks to end its three-game losing streak in front of its home crown. The 49ers have won four of their last six games at home against Indianapolis.
Kickoff from Levi's Stadium is set for 8:20 p.m. ET. San Francisco is favored by 3.5-points in the latest Colts vs. 49ers odds from Caesars Sportsbook, while the over-under is 42. Before locking in your 49ers vs. Colts picks, make sure you check out the NFL predictions from the red-hot SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up almost $7,700 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 7 of the 2021 season on an incredible 125-85 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated Colts vs. 49ers 10,000 times and just revealed its NFL picks and predictions. You can head to SportsLine now to see the model's NFL picks. Now, here are several NFL odds and betting trends for Colts vs. 49ers on SNF:
Colts vs. 49ers spread: San Francisco -3.5 Colts vs. 49ers over-under: 42 points Colts vs. 49ers money line: San Francisco -175, Indianapolis +150 IND: The Colts are 7-2 against the spread in their last nine road games SF: The under is 5-0 in 49ers' last five games following a bye weekFeatured Game | San Francisco 49ers vs. Indianapolis Colts
The Colts have made it difficult for their opponents to score a rushing touchdown this season. In fact, they've allowed the fewest rushing touchdowns in the NFL with only one. The Colts defense has two stud linebackers flying around. Bobby Okereke leads the team in total tackles with 51, including 31 solo. The Stanford product had a monster game last week, recording a season-high 14 total tackles with nine solo.
Darius Leonard is second on the team in total tackles with 45, including 28 solo. Leonard has also caught two interceptions and recovered two fumbles on the year. Indianapolis' front four has also wrecked havoc, recording 12 sacks on the year. Plus, the Colts have covered the spread in four of their last five games.
Why the 49ers can coverHead coach Kyle Shanahan and the 49ers are optimistic that quarterback Jimmy Garoppolo will return from injury. Garoppolo suffered a calf injury against the Seattle Seahawks in Week 4, causing him to miss the following game.
The 49ers have the sixth-ranked total defense and allow 329.8 total yards per game. This unit is led by All-Pro linebacker Fred Warner and defensive end Nick Bosa. Warner leads the 49ers in total tackles with 45, including 29 solo. He has recorded at least nine tackles in four of the five games played. Bosa leads San Francisco with eight tackles for loss and five sacks. The Ohio State product has recorded a sack in four of the team's five games on the year.
How to make Colts vs. 49ers picksSportsLine's model is leaning over on the point total, projecting the teams to combine for 45 points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only see the model's 49ers vs. Colts picks at SportsLine.
So who wins 49ers vs. Colts on Sunday Night
