Two playoff contenders trying to overcome the loss of major offensive contributors will square off Sunday when the Tennessee Titans host the New Orleans Saints. The Titans (7-2) will play their second game without running back Derrick Henry, who is out for at least six weeks with a broken foot. Meanwhile, the Saints (5-3) will play their second game without quarterback Jameis Winston, who is out for the rest of the season with ACL and MCL injuries to his left knee. Tennessee is a three-point favorite in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets and NFL parlays?
Other key matchups include the Packers hosting the Seahawks and the Browns taking on the Patriots. Before making any Week 10 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 10. If you successfully parlay its picks, you'd be looking at a massive payout of 25-1. You can only see the model's Week 10 NFL picks at SportsLine.
Top Week 10 NFL picksAfter simulating every game 10,000 times, the model is high on the Broncos to cover as 2.5-point favorites at home against the Eagles. The Broncos (5-4) sit just a half-game behind the Chargers and Raiders (both 5-3) in the crowded AFC West. Meanwhile, the Eagles (3-6) occupy second place in the woeful NFC East behind the division-leading Cowboys (6-2).
Denver has one of the stingiest defenses in the league. The Broncos allow just 17.0 points per game, which ranks second in the NFL behind only Buffalo. They are coming off a game in which they limited Dak Prescott and the high-flying Cowboys to just 16 points and 290 total yards despite having traded franchise career sacks leader Von Miller earlier in the week.
How to make Week 10 NFL parlaysThe model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two teams fighting for their playoff lives. You can only see the model's NFL Week 10 best bets and parlay at SportsLine.
What are the model's top Week 10 NFL picks? And which other matchups should you target for an epic
