Monday Night Football odds, spread, line: Rams vs. 49ers picks, NFL predictions from expert on 37-19 roll

Monday Night Football odds, spread, line: Rams vs. 49ers picks, NFL predictions from expert on 37-19 roll
Monday Night Football odds, spread, line: Rams vs. 49ers picks, NFL predictions from expert on 37-19 roll

The Los Angeles Rams will try to bounce back from just their second loss of the season when they take on the San Francisco 49ers on Monday Night Football. The Rams (7-2) saw their four-game winning streak end last week with a 28-16 loss to Tennessee. They dropped to second place in the NFC West, a half-game game behind Arizona (8-2). The 49ers (3-5) are battling with Seattle for the bottom of the division. They have lost five of their last six games. 

Kickoff is set for 8:15 p.m. ET. Los Angeles is a 3.5-point favorite in the latest Rams vs. 49ers odds from Caesars Sportsbook, while the Over-Under for total points scored is 50.5. Before you make any 49ers vs. Rams picks of your own, you need to see what NFL expert R.J. White has to say.

White, a CBS Sports fantasy and gambling editor, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White is an amazing 37-19-1 on his last 57 against-the-spread picks involving the Rams, returning $1,576 to $100 players. Anyone who has followed him is way up.

Now, he has locked in on Rams vs. 49ers and released a confident against-the-spread pick. Go here to see it. Here are the NFL lines and trends for 49ers vs. Rams:

Rams vs. 49ers spread: Los Angeles -3.5 Rams vs. 49ers Over-Under: 50.5 points Rams vs. 49ers money line: Los Angeles -190, San Francisco +160 LAR: QB Matthew Stafford leads the league in passing yards (2,771) SF: WR Deebo Samuel ranks second in the NFL in receiving yards (882) Why the Rams can cover

Cooper Kupp is having the best season of any receiver in the league. The 28-year-old from Eastern Washington leads the NFL in receiving yards per game (113.2), receptions (74) and receiving touchdowns (10) entering Week 10. Last week, he had 11 catches against the Titans, which tied a career-high.

In addition, Los Angeles has been excellent on the road this season. The Rams have won all four games away from SoFi Stadium, including victories at Indianapolis and Seattle. They are one of just three teams, Arizona and New England being the other two, that were undefeated on the road entering the week.

Why the 49ers can cover

Receiver Deebo Samuel is having an all-Pro season. The wideout from South Carolina ranks second in the NFL in both receiving yards per game (110.3) and total receiving yards (882). He also has 49 catches (12th in the league) and four touchdown receptions (17th).

In addition, San Francisco has been highly efficient in the red zone this season. The team has scored 14 touchdowns on 22 drives, and its 77 percent red zone efficiency rate leads the NFL.

How to make Rams vs. 49ers picks

White has analyzed this matchup and while we can tell you he's leaning Under the total, he has discovered a crucial x-factor that makes one side of the spread a must-back. He's sharing it only at SportsLine.

Who wins 49ers vs. Rams on Monday Night Football? And what critical factor makes one side of the spread a must-back? Visit SportsLine

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