NFL odds, lines, picks, spreads, best bets, predictions for Week 12, 2021: Model backing Steelers, Patriots

Cincinnati and Pittsburgh will try to make a move in the AFC North when they square off Sunday as part of the Week 12 NFL schedule. The Bengals improved to 6-4 with a blowout win over the Raiders last week, while Pittsburgh fell to 5-4-1 in a loss to the Chargers. Baltimore continues to lead the division with its 7-3 record and will try to maintain its lead when it faces Cleveland on Sunday night. The Bengals are 4.5-point favorites over the Steelers in the latest Week 12 NFL odds at Caesars Sportsbook. Which team can cover one of the larger NFL spreads of the week?

Baltimore is a 3.5-point favorite over the Browns in the NFL Vegas odds. All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,300 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 12 of the 2021 season on an incredible 130-91 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

One of the model's strongest Week 12 NFL picks is that the Steelers (+4.5) cover the spread against the Bengals. Pittsburgh got quarterback Ben Roethlisberger back and came up just short against the Chargers last week, but the model likes their chances to cover the spread in Week 12. Cincinnati is coming off a 32-13 win over the Raiders and is neck-and-neck with the Ravens and Steelers in an AFC North race that could go to the end of the season.

The Steelers should benefit by having Roethlisberger back for a full week of practice after missing last week with COVID-19. The model projects Roethlisberger to go toe-to-toe with Bengals quarterback Joe Burrow, with each projected for 240 yards through the air on Sunday. In simulations from SportsLine's model, Pittsburgh covers the spread well over 50 percent of the time. The Steelers also win straight-up in well over 40 percent of simulations, making them a candidate on the money line.

Another one of its Week 12 NFL predictions: The Patriots (-7) cover against the Titans. The Patriots are the hottest team in the NFL, rattling off five consecutive wins coming into this week's game. They opened as 2.5-point home favorites, but are now seven-point favorites following Tennessee's shocking loss to Houston. The Titans were unable to overcome a four-interception game from quarterback Ryan Tannehill, who will be without his top two receivers.

New England's defense has allowed an average of just 169.6 passing yards per game during the five-game winning streak. The Patriots have outscored their opponents 175-50 over that span. SportsLine's model says New England covers the spread in more than 50 percent of simulations. The over (44) also cashes more than 50 percent of the time.

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,300 since its inception, and find out.

Week 12 NFL odds, spreads, lines

Sunday, Nov. 28

Titans at Patriots (-7, 44)

Featured Game | New England Patriots vs. Tennessee Titans