NFL odds, lines, picks, spreads, best bets, predictions for Week 13, 2021: Model loving Colts and Broncos

The 49ers and Seahawks will meet on the Week 13 NFL schedule in an NFC West matchup with plenty of consequences. The 6-5 49ers are three-point favorites in the Week 13 NFL odds at Caesars Sportsbook, with the Seahawks coming in with a 3-8 record as they stare down existential questions about their team. With San Francisco looking toward the NFL playoff picture and Seattle trying to show they aren't as soft as their record, who will cover one of the smallest NFL spreads of the week?

The Cardinals, who comfortably lead the NFC West, face the 4-7 Bears. Arizona is favored by 7.5 points in the Week 13 NFL Vegas odds at Caesars. Which of these games, and the rest of the Week 13 NFL betting lines, deserve your attention? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 13 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up almost $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 13 of the 2021 season on an incredible 131-94 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 13 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 13 NFL predictions

One of the model's strongest Week 13 NFL picks is that the Colts (-10) cover the spread against the Texans with points to spare. The Colts have been motoring along after losing three straight games to open the season. Behind a star turn from running back Jonathan Taylor and steady play from quarterback Carson Wentz, they've gone 6-3 since their stumble out of the gate. The Texans, meanwhile, were only able to muster 202 total yards of offense in a 21-14 loss to the Jets last week and are 2-9 on the season.

The Colts cover the spread in 60 percent of simulations from SportsLine's model, making them a top pick for your Week 13 NFL bets. The point total sits at 45.5, and the under hits in well over 50 percent of SportsLine's simulations.

Another one of the model's Week 13 NFL predictions: The Broncos (+9.5) cover against the Chiefs at Arrowhead. It's the third-largest spread of the week, per the Week 13 NFL Vegas odds at Caesars Sportsbook, and SportsLine's model sees an opportunity for anyone willing to take a large underdog. Kansas City has found itself again after early season struggles, but this game will test how potent the Chiefs really are.

The Broncos may have traded away Von Miller, but their defense has still held opponents under 400 total yards in their last four games. Quarterback Teddy Bridgewater has been cooking up a strong season that has supplied the team with enough competent play to win games. SportsLine's model projects him to get an assist from running backs Melvin Gordon and Javonte Williams, both of whom the model projects to get 60 yards on five yards per carry. SportsLine's simulations have Denver covering the spread well over 60 percent of the time.

How to make Week 13 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 13 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,100 since its inception, and find out.

Week 13 NFL odds, spreads, lines

Sunday, Dec. 5

Vikings at Lions (+7.5, 46.5)

Cardinals at Bears (+7.5, 42.5)

Buccaneers at Falcons (+10.5, 50.5)

Colts at Texans (+10, 44.5)

Eagles at Jets (+7, 45)

Chargers at Bengals (-3, 50)

Giants at Dolphins (-6, 39.5)

Washington at Raiders (-1.5, 49.5)

Jaguars at Rams (-13, 48)

Ravens at Steelers (+4.5, 44)