But with passage to the knockout stages already in the bag for United, Young Boys' visit to Old Trafford is a mere formality for the Group F winners.
Ralf Rangnick has hinted at a number of changes for Man United ahead of Young Boys game
Anthony Martial and Jesse Lingard joined an overloaded United treatment table with Luke Shaw, Raphael Varane, Paul Pogba and Edinson Cavani also sidelined.
Despite his limited options, the interim boss could look to capitalise on the stress free fixture, resting the usual starting stars and giving United's prodigies a run out.
The 63-year-old favours a 4-2-2-2 formation and after finding success in that shape against Palace, he could line up in the same way this week.
Here, Sportsmail takes a look at how the interim boss could line up to face Young Boys in their final group stage game.
Henderson has become a forgotten man at Old Trafford this season since David De Gea's United renaissance.
The 24-year-old is yet to make a Premier League or Champions League appearance for United in the current campaign, only featuring in their 1-0 Carabao Cup defeat at home to West Ham back in September.
The youngster looked likely to usurp De Gea as Ole Gunnar Solskjaer's No 1 heading into the new season but a bout of Covid forced him to lay low, handing the Spaniard the golden opportunity to break back into the side.
But with Champions League last 16 already in their grasp, Rangnick has confirmed he will be switching Henderson in between the sticks this week.
Dean Henderson has become a forgotten man this season with David De Gea getting the nod
Rangnick opted to field Diogo Dalot in the right-back position against Palace with Wan-Bissaka consigned to the bench.
Dalot's nod ahead of Wan-Bissaka came as a surprise after the Portuguese full-back had been left out in the cold by Solskjaer.
But Rangnick has been clear about the style of football he wants to foster at United and the German requires his full-backs to be adept with the ball - something Wan-Bissaka has not been to strong on lately.
But the interim manager could give Wan-Bissaka the chance to prove himself against Young Boys with a view to resting Dalot for their trip to Carrow Road at the weekend.
Aaron Wan-Bissaka (L) was consigned to the bench for the game against Crystal Palace
The England international came under increasing pressure towards the end of Solskjaer's tenure but Rangnick will be looking to maintain some stability within the squad to steer them out of troubled waters.
Though the game against Young Boys is a dead rubber for United, the new boss will not want to hit a bump in the road so soon into his reign.
As captain, Maguire's leadership from the back should bring calm and confidence to a relatively changed side that will allow them to maintain their newfound winning momentum.
Victor Lindelof received the nod ahead of the Ivory Coast centre back on Sunday but while Rangnick is likely to keep Maguire in the side his defensive partner could be swapped out.
The German boss could look to give Bailly some game time in a relatively straight forward fixture.
Bailly has only made one Champions League appearance this season and will be desperate to prove himself in the new managerial regime.
Alex Telles is set to make up the defensive shield at left back as one of the few unchanged players from the Palace win.
Luke Shaw was ruled out of Sunday's game following a head injury sustained against Watford and is expected to remain sidelined this week.
The England international enjoyed an excellent campaign last season but struggled for form as Solskjaer crashed and burned