It may be too early to start calling it a 'top four six-pointer' but Arsenal's clash with West Ham does look like it could set the tone for the race for Champions League football in the second half of the season.
Both teams have put in timid efforts for the top four in recent years, but have fallen short to be left with either Europa League football or no European contest at all.
But with Tottenham and Manchester United suffering from cancellations due coronavirus outbreaks, Wednesday night's clash at the Emirates Stadium hands both sides the chance to steal a march in the top four race.
All the pressure is on Arsenal as they host West Ham in a crucial top-four battle on Wednesday
David Moyes' Hammers currently lie in fourth ahead of their trip to the Emirates Stadium
The winner will sit in fourth spot going into the next round of games, while the other will be sat scratching their heads and thinking about other ways of getting Europe next season.
While West Ham are the frontrunners, the pressure does lie at the feet of Arsenal and especially their manager Mikel Arteta.
This is a pivotal moment in the Spaniard's reign in north London as he looks to drive the Gunners away from inconsistent results and into a solid top-four challenge.
The north Londoners have recovered from their pointless and tricky start to the campaign to sit in the top six, but their main Achilles heel this season has been their results against top-quality opposition.
Under-fire Gunners boss Mikel Arteta cannot afford another big-game slip-up this season
Recent big-game losses to Liverpool and Manchester United have highlighted a trend of the Gunners failing to turn up in matches they need to win - and Wednesday's clash with West Ham is nothing short of a big game.
The Hammers, meanwhile, have an excellent record of turning up when it matters. Recent home victories over Tottenham, Chelsea, Manchester City and Liverpool have shown David Moyes' side can turn up for the big occasion - but it's their away form which particularly impresses.
Moyes' men have lost just twice on the road in all competitions this season - with one of those defeats coming against Premier League champions City. Their stellar away record in their Europa League group stage shows that nothing fazes them.
West Ham have history of turning up for big games including wins over Chelsea and Liverpool
Arsenal, meanwhile, have won six out of their eight home matches in the Premier League
But perhaps Arsenal's excellent home form will? The Gunners have the second-best record on their own patch in the Premier League this season with six victories in their eight games at the Emirates, with Arsenal scoring in all but one of those matches.
Little can separate either sides' form but the two teams are also united in their inconsistent results in recent
