Manchester City's one-goal victory over title rivals Chelsea on Saturday could be the final blow, in a title race which now sees the champions having an 11-point lead to Liverpool at the top.
Even with just over four months to go until the final day on May 22, and even though the Reds have a game in hand, it would take an unfathomable collapse from Pep Guardiola's juggernaut to see the title slip away now.
Yet despite the title race being all but over, there are still plenty of stories to be written in the remainder of this Premier League campaign - and Sportsmail takes you through all the reasons to remain excited in 2022.
Man City's victory over title rivals Chelsea on Saturday could be the final blow in the title race
Despite the title slipping away for Liverpool and Chelsea, there are still reasons to get excited
A TOP-FOUR BATTLE IN LONDON
While the top three are very much in a league of their own, the battle for the fourth and final Champions League spot is looking set to go down to the wire.
The current occupants of fourth place are David Moyes' high-flying West Ham, whose aspirations were dealt a blow after a home defeat to Leeds on Sunday.
The Hammers are two points clear of Arsenal in fifth, who have two games in hand after their north London derby clash with Tottenham was postponed at the weekend.
Spurs themselves are two points further back but have two games in hand on the Gunners - and four on West Ham.
So often a talking point come the final day of the campaign, the race to be in Europe's flagship competition come next season will go back and forth in the weeks and months to come.
Rivals Arsenal and Tottenham are among three London teams fighting for a top-four spot
WILL RONALDO MISS OUT ON CHAMPIONS LEAGUE FOOTBALL?
Since moving to Manchester United - for the first time - in 2003, Cristiano Ronaldo has not missed a single Champions League season and has never played in the Europa League.
Yet, as things stand, the five-time Ballon d'Or winner won't even be playing in Europe's secondary competition.
Instead, amid a first half of the season which saw a sacking and players out of form, United's current position of seventh would see them qualify for the new third-tier European competition, the UEFA Conference League.
For Ronaldo, that would constitute quite the embarrassment upon his comeback to Old Trafford.
The Portuguese legend and his team-mates now being led by Ralf Rangnick, has time to turn things around. They are just a point behind Tottenham, but it is very much an uphill task after just one win in their last four league games.
