The Buffalo Bills have established themselves as the top team in the AFC East after a run of dominance by New England that lasted nearly two decades. Buffalo has won back-to-back division titles and is the +600 favorite at Caesars Sportsbook to win the first Super Bowl title in franchise history this season. The Bills, who have been eliminated by Kansas City the last two postseasons, will begin that quest on Thursday when they visit the reigning champion Los Angeles Rams in the 2022 NFL Kickoff Game.
Kickoff from SoFi Stadium is set for 8:20 p.m. ET. Buffalo is a 2.5-point favorite in the latest Bills vs. Rams odds from Caesars Sportsbook, while the over/under for total points scored is 52. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated Bills vs. Rams in the NFL Kickoff Game 2022 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Rams vs. Bills:
Bills vs. Rams spread: Buffalo -2.5 Bills vs. Rams over/under: 52 points Bills vs. Rams money line: Buffalo -135, Los Angeles +115 BUF: Bills scored at least 31 points in 11 of their 19 games last season, including playoffs LAR: Rams have lost their last three home games against Buffalo Bills vs. Rams picks: See picks at SportsLineFeatured Game | Los Angeles Rams vs. Buffalo Bills
Buffalo may have exited last year's playoffs earlier than it hoped, but it also saw the emergence of a potential star. Second-year receiver Gabe Davis came up with a performance for the ages in the Bills' overtime loss to the Chiefs, making eight catches for a career-high 201 yards and postseason-record four touchdowns. The 23-year-old from UCF, who also hauled in a scoring pass in Buffalo's wild-card victory against New England, recorded 549 yards and six TDs in 16 games during the regular season.
With his effort versus Kansas City, Davis gives Josh Allen and the Bills' offense another dangerous weapon. The 26-year-old Allen, who threw nine TD passes and no interceptions in two games last postseason, already has formed strong bonds with wideout Stefon Diggs and tight end Dawson Knox. Diggs had 103 receptions for 1,225 yards and 10 scores while Knox registered career highs of 49 catches, 587 yards and nine touchdowns.
Why the Rams can coverLos Angeles has been superb in season-openers under Sean McVay, winning and covering the spread in all five games since he became coach in 2017. The team has gone 55-26 overall with McVay at the helm, the third-best mark in the NFL during that span. The Rams' success in Week 1 goes back much further, as it owns a 19-3 record since 2000.
Matthew Stafford couldn't have done much more in his first season with Los Angeles, as he guided the Rams to the second Super Bowl championship in franchise history after ranking third in the NFL in passing yards (4,886) and second in touchdown tosses (41) during the regular season. The 34-year-old, who was the first overall pick in the 2009 NFL Draft and spent 12 campaigns with Detroit before being acquired in March 2021, was stellar in the fourth quarter in 2021. Including the postseason, Stafford threw 14 TD passes without an interception during the final 15 minutes of regulation.
How to make Rams vs. Bills picksSportsLine's model is leaning Under on the total, projecting the teams to combine for 49 points. It also says one side of the spread cashes in well over 50% of simulations. Head to SportsLine to
