NFL odds, lines, picks, spreads, best bets, predictions for Week 2, 2022: Model backing Browns, Cardinals

After playing in last Thursday's season opener, the Buffalo Bills won't take the field again until Monday Night Football in Week 2, giving them a prolonged mini-bye. With the extra rest, Josh Allen, Stefon Diggs and company are 10-point favorites over Derrick Henry's Titans in the latest Week 2 NFL odds from Caesars Sportsbook. However, when these teams squared off last season, Tennessee outright won as six-point underdogs. Will recent history affect your decision when laying down your Week 2 NFL bets based on the latest NFL spreads? All of the Week 2 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 2 NFL picks now. 

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 2 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 2 NFL predictions

One of the model's strongest Week 2 NFL picks is that the Browns (-6.5) cover at home against the Jets. Cleveland spoiled Baker Mayfield's revenge party with a road victory over Carolina in Week 1 in which it dominated in the trenches on offense and defense. The Browns ran for 217 yards, as Nick Chubb and Kareem Hunt combined for over 200 scrimmage yards and two touchdowns. Cleveland's defensive line took control of the game from there and sacked Mayfield four times. The former Browns quarterback also fumbled four times.

Meanwhile, New York is coming off a 24-9 defeat to the Ravens in which it showed that not much has changed from last year. In 2021, the Jets ranked 28th in scoring offense and they failed to find the end zone on their first 11 drives against Baltimore before punching in a touchdown in garbage time on their final drive. Joe Flacco will remain the team's QB with Zach Wilson (knee) still out, and the former Ravens' lack of mobility was glaring, as he was sacked three times while throwing a pick. The model says the Browns sack Flacco four times, a big reason why it has Cleveland (-6.5) covering in almost 60 percent of simulations. See who else to back here.

Another one of its Week 2 NFL predictions: The Cardinals (+4.5) cover the spread on the road versus the Raiders. During the preseason, Las Vegas infamously cut its 2021 first-rounder, OT Alex Leatherwood, hoping it would be addition by subtraction. But that move certainly didn't pay off in Week 1, as Derek Carr was pressured 14 times, or 33 percent of his drop-backs. The Raiders were sacked six times and Carr tied a career-high of three interceptions in a loss to the Chargers.

As for the Raiders' pass rush, it failed to register a single sack despite having a Pro Bowl duo of defensive ends in Maxx Crosby and Chandler Jones. Kyler Murray's mobility will only make Vegas' task in bringing a QB down even more difficult. Plus, Murray has quietly been in a highly efficient streak dating back to last year. Over his last four regular-season games, the Heisman winner has six touchdown passes and zero turnovers.

The model sees Arizona's Week 1 loss to the Chiefs as an outlier. SportsLine's model has Arizona going on the road and covering in over 60 percent of simulations. See which other teams to pick here.

How to make Week 2 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 2 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,500 since its inception, and find out.

Week 2 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Thursday, Sept. 15

Chargers at Chiefs (-3.5, 54)

Sunday, Sept. 18

Dolphins at Ravens (-3.5, 43.5)

Jets at Browns (-6.5, 40.5)

Colts at Jaguars (+4, 46.5)

Buccaneers at Saints (+3, 45.5)

Panthers at Giants (-2.5, 42.5)

Patriots at Steelers (+1, 41)

Commanders at Lions (-2, 48.5)

Seahawks at 49ers (-8.5, 42.5)

Falcons at Rams (-10, 47.5)

Texans at Broncos (-10, 43.5)

Cardinals at Raiders (-4.5, 51.5)