NFL odds, lines, picks, spreads, best bets, predictions for Week 3, 2022: Model selecting Bengals, Seahawks

Entering Week 3 of the 2022 NFL schedule, there are only six teams that remain unbeaten, and two of them will go head-to-head on Sunday. The Dolphins and Bills are coming off weeks in which they put up more than 40 points, but the Bills have been the stronger defensive unit this season and are 5.5-point road favorites in the Week 3 NFL odds from Caesars Sportsbook. In another pivotal division matchup, the Vikings are six-point favorites at home against the Lions in the NFL spreads and NFL Vegas lines. Which games should you target as you place your Week 3 NFL bets and which NFL Vegas odds should you avoid? All of the Week 3 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 3 NFL picks now. 

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 3 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 3 NFL predictions

One of the model's strongest Week 3 NFL picks is that the Bengals (-6) go on the road and cover against the Jets. The Jets are coming off a miraculous win over the Browns in which they erased a 13-point deficit in the final two minutes, while the Bengals are off to a dismal 0-2 start. However, this looks like an opportunity to reset for the defending AFC champions against a team they should match up with well.

The Bengals' two losses have come by a combined six points and they've managed to stay competitive despite turning the ball over five times in Week 1 against the Steelers and allowing Joe Burrow to be sacked 13 times in two weeks. The Bengals' defense is only allowing 3.7 yards per carry (seventh in the NFL) and could make the Jets one-dimensional after they only managed 176 rushing yards total the first two games. The model has Burrow throwing for 300 yards and two touchdowns to help Cincinnati cover in nearly 60 percent of simulations.

Another one of the model's Week 3 NFL predictions: The Seahawks (-1) cover the spread at home versus the Falcons. Seattle is coming off a tough road loss to San Francisco, but it looked strong at home in a 17-16 upset win over Denver in Week 1. Seahawks quarterback Geno Smith has been efficient so far this season, completing 47 of 58 passes for 392 yards, two touchdowns and one interception.

He will face an Atlanta defense that allowed 27 points to the Saints in Week 1 and 31 points to the Rams last week. The Falcons might have covered the spread against Los Angeles last week, but they trailed 31-10 in the fourth quarter before the Rams let off the gas pedal. Seattle has won and covered the spread in three of its last four games. SportsLine's model has Smith throwing for 200 yards and at least one touchdown, while running backs Rashaad Penny and Kenneth Walker III combine for more than 100 rushing yards in the latest simulations. Their success leads to Seattle covering the spread well over 50% of the time. See which other teams to pick here.

How to make Week 3 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 3 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.

Week 3 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Sept. 25

Chiefs at Colts (+5.5, 50.5)

Ravens at Patriots (+3, 44)

Saints at Panthers (+2.5, 41)

Texans at Bears (-2.5, 40)

Bills at Dolphins (+5.5, 52.5)

Lions at Vikings (-6, 52.5)

Bengals at Jets (+6, 45)

Raiders at Titans (+2, 45.5)

Eagles at Commanders (+6.5, 47)

Jaguars at Chargers (-3, 42.5)

Packers at Buccaneers (PK, 42)