NFL DFS for 49ers vs. Broncos: DraftKings, FanDuel daily Fantasy football picks for Sunday Night Football

NFL DFS for 49ers vs. Broncos: DraftKings, FanDuel daily Fantasy football picks for Sunday Night Football
NFL DFS for 49ers vs. Broncos: DraftKings, FanDuel daily Fantasy football picks for Sunday Night Football

Both the Broncos and 49ers rebounded from Week 1 losses to earn their first win of the season in Week 2 and now the two proud franchises will square off on Sunday Night Football. Russell Wilson's first two games in Denver have been far from prolific but the 49ers will have to readjust to having Jimmy Garoppolo as their starter after Trey Lance's season-ending injury last week. Rostering a quarterback during a single-game NFL DFS slate is a virtual necessity, so can either of those QBs put up big numbers on Sunday night?

The Broncos and 49ers both rank inside the top-five in scoring defense, making your NFL DFS roster decisions that much harder. So which players should be included in your NFL DFS lineups for 49ers vs. Broncos? Before making your NFL DFS picks on sites like DraftKings and FanDuel, you need to see the NFL DFS advice, strategy and player projections from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments. 

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Last week, McClure featured Chargers wide receiver Mike Williams in his Thursday Night Football NFL DFS picks for Los Angeles vs. Kansas City. The result: Without Keenan Allen (hamstring) available, Williams went off for 113 yards and a touchdown in a loss to the Chiefs.

Now, McClure has turned his attention to 49ers vs. Broncos and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Broncos vs. 49ers 

One of McClure's top NFL DFS picks for Sunday Night Football is Broncos quarterback Russell Wilson. Denver has only managed to score 16 points in both of their two games this season but Wilson has actually been fairly productive. He's averaging 7.7 yards per pass attempt and has thrown for 559 yards and two scores with just one interception.

Wilson hasn't made a particularly large impact with his legs so far this season, rushing for just five yards in the first two games. However, he's rushed for 4,694 yards and 23 touchdowns in his career and has had at least 20 rushing yards in five of his last six games against San Francisco.

Part of McClure's optimal NFL DFS strategy also includes rostering 49ers wide receiver Deebo Samuel. The most versatile offensive threat in the league is coming off a massive season where he produced 1,770 yards from scrimmage. He also scored 14 touchdowns to earn himself a three-year, $71.55 million extension during the offseason.

With his contract in place to eliminate any concerns about his potential usage out of the backfield, the 49ers are now free to use him in any way they see fit and Samuel is once again making an impact as a runner and receiver. He has seven catches for 58 yards and has carried the ball 12 times for 105 yards and a touchdown. You can see the rest of McClure's NFL DFS advice here.

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