Nathaniel Hackett leads the Denver Broncos (1-1) into battle against Kyle Shanahan and the San Francisco 49ers (1-1) on Sunday Night Football. Broncos quarterback Russell Wilson will be up against a familiar foe in this matchup. He is 16-4 against San Francisco throughout his career. Meanwhile, Jimmy Garoppolo will be making the start for the 49ers after quarterback Trey Lance suffered a season-ending ankle injury last week.
Kickoff is set for 8:20 p.m. ET from Empower Field at Mile High. San Francisco is favored by 1.5 points in the latest 49ers vs. Broncos odds from Caesars Sportsbook, and the over/under is 45. Before making any Broncos vs. 49ers picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Broncos vs. Niners and just locked in its picks and SNF predictions. You can visit SportsLine now to see the picks. Here are the NFL odds and betting lines for Niners vs. Broncos:
Broncos vs. 49ers spread: San Francisco -1.5 Broncos vs. 49ers over/under: 45 points Broncos vs. 49ers money line: Denver +100, San Francisco -120 SF: The 49ers are 6-1 ATS in their last seven games overall DEN: The Under is 6-0 in Broncos' last six games in September Broncos vs. 49ers picks: See picks hereFeatured Game | Denver Broncos vs. San Francisco 49ers
Denver has been able to run the ball effectively in the first two games. This unit is ninth in the NFL in rushing yards per game (126) with 4.9 yards per carry. They have a strong duo at running back headlined by Javonte Williams. The North Carolina product is a dynamic tailback who knows how to make defenders miss. Williams can be a force once he gets downhill.
He is leading the team in rushing yards (118) on 22 carries with 5.4 yards per carry. The 2021 second-round pick can also be a secure pass-catcher. Williams has caught 12 passes for 75 yards. Melvin Gordon is another powerful running back for Denver, as the Wisconsin product has 22 carries for 105 yards, or 4.8 yards per carry.
Why the 49ers can coverThe 49ers have been playing dominating and stifling defense. Through two games, San Francisco ranks first in the NFL in total defense (210), first in passing yards (142.5), and second in rushing yards (67.5). This group knows how to make things difficult on the offense and cause havoc.
Defensive end Nick Bosa is a disruptive force coming off the edge. Bosa has an unbelievable motor with good speed to get around the corner. The Ohio State product has nine total tackles, three TFL's and three sacks. Safety Talanoa Hufanga is off to a solid start for San Francisco. Hufanga plays well in the box as a run defender while owning the coverage skills to line up against tight ends/running backs. The USC product is leading the team in total tackles (17) with three tackles for loss, three pass deflections, and one interception.
How to make Broncos vs. 49ers picksSportsLine's model is leaning Under on the total, projecting the teams to combine for 42 points. It also says one side of the spread cashes in more than 50% of simulations. You can only get the model's SNF picks at SportsLine.
So who wins 49ers vs. Broncos on Sunday
