The 100th game played outside of the United States highlights the Week 4 NFL schedule when the Minnesota Vikings face the New Orleans Saints in London. The contest will be the 41st regular-season international game and 31st to take place in England. Minnesota and New Orleans both are 2-0 in London, with each team posting its most recent victory in 2017. The Vikings (2-1) are coming off a 28-24 home win against Detroit, while the Saints (1-2) suffered a 22-14 setback at Carolina last week. Minnesota is a 3-point favorite against New Orleans in the latest Week 4 NFL odds at Caesars Sportsbook. Which Week 4 NFL lines should you target with your Week 4 NFL bets? Before you make any Week 4 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model. The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. Now, the model has locked in five confident NFL best bets for Week 4. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 4 NFL picks at SportsLine. Top Week 4 NFL picks After simulating every game 10,000 times, the model is high on the Pittsburgh Steelers (-3.5) to win and cover against the New York Jets on Sunday. Even though reigning NFL Defensive Player of the Year T.J. Watt is sidelined with a pectoral injury he suffered in the season-opening overtime win at Cincinnati, the Steelers still have a player who can get to the quarterback, Alex Highsmith. The 25-year-old linebacker leads the league with 4.5 sacks after registering 1.5 in Pittsburgh's 29-17 loss at Cleveland last week. That's bad news for New York's Zach Wilson, who is expected to make his season debut after missing three games with a knee injury. The 23-year-old quarterback had a rough rookie campaign in 2021 as he was sacked 44 times, the third-most in the league, in just 13 games. The Jets allowed nine sacks over their first three games this year, one reason Pittsburgh is covering the spread in over 50% of simulations. See which other NFL parlay picks to make here. How to make Week 4 NFL parlays The model also jumped on four other NFL matchups where it says the line is way off, including backing a pair of underdogs. You can only see the model's NFL Week 4 best bets and parlay at SportsLine. What are the model's top Week 4 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from a model on a 139-103 run on its top-rated picks, and find out.