Colts vs. Titans odds, line, spread: 2022 NFL picks, Week 4 predictions from proven computer model

Colts vs. Titans odds, line, spread: 2022 NFL picks, Week 4 predictions from proven computer model
Colts vs. Titans odds, line, spread: 2022 NFL picks, Week 4 predictions from proven computer model

It's been a tough start to the season for the Tennessee Titans (1-2), who dropped their first two games and have lost stars Harold Landry (knee) and Taylor Lewan (knee) for the year already. But they rallied on a short week against the Raiders in Week 3 to pick up their first victory, and now they'll head to Indianapolis looking to get back to .500 as they take on the Colts (1-1-1) during the Week 4 NFL schedule. Indianapolis looked lifeless in a 24-0 loss to the Jaguars in Week 2, but the Colts bounced back with a 20-17 upset of the Kansas City Chiefs in Week 3.

Kickoff is set for 1 p.m. ET at Lucas Oil Stadium in Indianapolis. Caesars Sportsbook lists Indianapolis as the 3.5-point favorite in the latest Titans vs. Colts odds. The over/under for total points is set at 43. Before entering any Colts vs. Titans picks, you'll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Titans vs. Colts. You can head to SportsLine to see its picks. Here are several NFL betting lines for Colts vs. Titans:

Titans vs. Colts spread: Colts -3.5 Titans vs. Colts over/under: 43 points Titans vs. Colts picks: See picks here

Featured Game | Indianapolis Colts vs. Tennessee Titans

Why the Titans can cover

It was a gut-check win for the Titans in Week 3 as they held off a Las Vegas rally in a 24-22 final. Tennessee was in control for most of the contest, but allowed the Raiders to stick around. The Raiders scored late, but failed to convert a 2-point conversion that would've tied it. That got Tennessee in the win column for the first time after dropping games to the Giants and Bills to open the season.

Though the Titans are missing multiple key pieces due to injury, Tennessee does have a healthy Derrick Henry. He went for more than 150 all-purpose yards and a touchdown in the Week 3 win. Tennessee's passing attack also showed some life in Week 3 as Ryan Tannehill completed at least one pass to seven different players as he finished the day with 264 yards through the air. 

Why the Colts can cover

Like Tennessee, the Colts looked to be in trouble through two weeks, but bounced back in a big way in Week 3. Indianapolis put up one of the more impressive wins in the league, knocking off the Chiefs 20-17. Indy's defense held the high-powered Kansas City offense to just 3 of 10 on third-down conversion attempts. The Colts also forced two turnovers. 

It hasn't been the best overall start for quarterback Matt Ryan through three weeks, but he settled in a bit against the Chiefs. He completed 72% of his passes for 222 yards, two touchdowns and no interceptions. Jonathan Taylor, who was back on the practice field Thursday and Friday after missing Wednesday's session due to a toe injury, remains perhaps the

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