The Los Angeles Rams (2-1) will head to Levi's Stadium to take on the San Francisco 49ers (1-2) on Monday Night Football. After starting the season 0-1, the Rams have won two straight games. In Week 3, Los Angeles beat a division foe, outlasting the Arizona Cardinals 20-12. Meanwhile, San Francisco traveled to Empower Field and lost to the Denver Broncos 11-10.
Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. San Francisco is favored by two points in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under is 42.5. Before making any 49ers vs. Rams picks, you have to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has broken down Monday's 49ers vs. Rams matchup and just locked in its picks and MNF predictions. You can head to SportsLine now to see the model's picks. Here are the NFL odds and betting lines for Rams vs. Niners:
Rams vs. 49ers spread: San Francisco -2 Rams vs. 49ers over/under: 42.5 points Rams vs. 49ers money line: Los Angeles +110, San Francisco -130 SF: 49ers are 5-0 ATS in their last five home games LAR: Rams are 4-1 ATS in their last five Monday games Rams vs. 49ers picks: See picks at SportsLineFeatured Game | San Francisco 49ers vs. Los Angeles Rams
Tight end George Kittle returned to the field last week, providing a spark for this offense. Kittle is a phenomenal run blocker who brings physicality to the ground game. The three-time Pro Bowler has soft hands with the ability to evade defenders. Kittle owns a rare combination of size and speed. In his last outing, the Iowa product reeled in five passes for 28 yards.
Receiver Brandon Aiyuk is a natural pass-catcher who knows how to create separation. Aiyuk has long arms and is able to swiftly track down deep passes. The Arizona State product is another YAC beast for this unit. He's explosive and quick to take any pass to the house for a score. He's leading the team with 142 yards on 10 grabs. Seven of those receptions resulted in first downs.
Why the Rams can coverThis defense is filled with dynamic difference-makers at all three levels who don't allow teams to establish a consistent ground attack as they quickly swarm the ball-carrier. This unit ranks 10th in the league in rushing yards allowed (93.7). Ernest Jones and Bobby Wagner form a formidable linebacker duo for the Rams.
Jones owns a strong IQ and has a nose for the football. The South Carolina native has a feel for blocking schemes and leverage. He's leading the team in total tackles (24) along with one forced fumble. Wagner is an athletic and instinctive force in the middle of the defense. The eight-time Pro Bowler came over in the offseason to provide another thumper and leader to this group. Wagner has recorded 23 total stops with two sacks.
How to make Rams vs. 49ers picksThe model has broken down Niners vs. Rams on Monday Night Football from all angles. It is leaning Under on the total, projecting 40 combined points. The model also says one side of the spread hits well over 50% of the time. You can only get the model's MNF picks at SportsLine.
So who wins 49ers vs. Rams on Monday Night Football? And which
