Week 12 of the 2022 NFL season concludes with a Monday Night Football matchup at Lucas Oil Stadium between the Indianapolis Colts and Pittsburgh Steelers. Indianapolis is 4-6-1 this season, including a 2-3 mark at home and a 1-1 mark under interim head coach Jeff Saturday. Pittsburgh is 3-7 overall and 1-4 on the road this season, though the Steelers have won seven straight games against the Colts. The Colts are looking to rebound from a 17-16 loss to the Philadelphia Eagles, while the Steelers are hoping to bounce back from a 37-30 loss to the Cincinnati Bengals. Kickoff is at 8:15 p.m. ET in Indianapolis. Caesars Sportsbook lists the Colts as 2.5-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 39.5 in the latest Steelers vs. Colts odds. Before you make any Colts vs. Steelers picks and NFL predictions, you need to see what SportsLine NFL expert R.J. White has to say. White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 NFL expert in picks against the spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 56-32-4 on his last 92 picks involving the Steelers, meaning he's well-qualified for this selection. He's well-known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. White also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed White is way up. Now, White has set his sights on Steelers vs. Colts and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for Steelers vs. Colts: Steelers vs. Colts spread: Colts -2.5 Steelers vs. Colts over/under: 39.5 points Steelers vs. Colts money line: Colts -140, Steelers +118 PIT: Steelers are 4-5-1 against the spread this season IND: Colts are 5-6 against the spread this season Steelers vs. Colts picks: See picks here Featured Game | Indianapolis Colts vs. Pittsburgh Steelers Why the Steelers can cover Pittsburgh has forced 14 turnovers, a top-eight mark, and the Steelers get consistent pressure with T.J. Watt on the field. Mike Tomlin's team is especially stout against the run, ranking seventh in rushing yards allowed per game (103.4). Pittsburgh is in the top five in rushing touchdowns allowed (five) and yards per carry allowed (3.9). The Colts are second-worst in scoring offense, generating only 15.7 points per game, and Indianapolis is scoring on fewer than 30% of offensive possessions. Indianapolis has 19 turnovers this season, and the Colts are in the bottom 10 in total yards, third down efficiency, and red zone efficiency on offense. See which team to pick here. Why the Colts can cover The Colts are in the top five in total defense, yielding 307.6 yards per game, and are giving up only 26.7 yards per possession. Indianapolis is No. 7 in yards allowed per play (5.0), and the Colts are in the top third of the league in scoring defense (20.0 points allowed per game) and points allowed per drive (1.65). Indianapolis is No. 7 in pass defense. Opponents are averaging only 194.2 passing yards per game and 7.0 yards per pass attempt against them, and the Colts have 28 sacks with only 13 passing touchdowns allowed. The Colts are also potent against the run, allowing only 113.5 rushing yards per game and nine rushing touchdowns this season. Indianapolis is No. 2 in allowing 3.8 yards per carry, and Pittsburgh projects to struggle with efficiency on the ground. See which team to pick here. How to make Steelers vs. Colts picks White has analyzed this matchup and while we can tell you he's leaning Under on the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine. Who wins Colts vs. Steelers on Monday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Colts vs. Steelers spread to back, all from the expert who is 56-32 on picks involving the Steelers, and find out.