NFL odds, lines, picks, spreads, best bets, predictions, office pool, new survivor picks for Week 13, 2022

There is only one double-digit favorite in the Week 13 NFL odds at Caesars Sportsbook, as Dallas is laying 11 points against Indianapolis on Sunday Night Football. The Cowboys backed up their blowout win over Minnesota with a comfortable victory over the Giants on Thanksgiving. Indianapolis has lost five of its last six games, including a 24-17 setback against Pittsburgh on Monday. Can you trust Dak Prescott, Ezekiel Elliott, CeeDee Lamb, and company to cover one of the largest NFL spreads of the season? Which teams should you target for your NFL office pool picks and NFL survivor picks? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 13 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2022 NFL season on an incredible 155-110 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 13 NFL odds and locked in NFL picks for every NFL matchup. Head here to see every pick.

Top Week 13 NFL predictions

One of the model's strongest Week 13 NFL picks is that the Giants (+2.5) cover the spread against the Commanders. Washington is still paying for a slow start to the season, but has won six of its last seven games. The Commanders play the Giants in consecutive games, but a Week 14 bye separates the two meetings.

The first matchup between the teams takes place at the Meadowlands, where the Giants will be hungry to pick up a win after they've lost three of their last four games. Taylor Heinicke has completed just 57% of his passes over his last four starts for Washington, and though the Commanders' ground game has been strong, they don't show much potential to run away with a big lead. See which other teams to pick here.

Top Week 13 NFL survivor picks

The model's Week 13 NFL knockout pool picks say to avoid the Chargers, even though they are favorites over the Raiders. Los Angeles is coming off a gutsy victory over the Cardinals in which head coach Brandon Staley electing to go for two rather than taking the extra point and the tie. Los Angeles wound up converting and went on to win 25-24. The Chargers are now back above .500 and in the thick of the AFC playoff picture.

However, the Chargers will face a confident Raiders team coming off back-to-back overtime wins. Las Vegas has gained 983 yards of total offense during that span and the Raiders have finally looked like the big-play offense that most were expecting when Josh McDaniels was hired and Davante Adams was acquired during the offseason. The Raiders have won four of the last seven meetings against the Chargers and the model is predicting they win outright well over 50% of the time. See which team you should pick here.

Top Week 13 NFL office pool picks

One of the strongest Week 13 NFL football pool picks from the model is that the Ravens beat the Broncos. There has been plenty of early betting action on Baltimore, quickly pushing the line from 6.5 to eight. The Ravens rank second in the NFL in rushing yards gained and rushing yards allowed, so they should control the time of possession on Sunday.

Denver continues to struggle this season, suffering its third straight loss in a 23-10 setback against Carolina last week. Quarterback Russell Wilson completed just 19 of 35 passes for 142 yards. Baltimore's offense has been improving of late, and quarterback Lamar Jackson gives the Ravens more firepower than Denver, which is one reason why they are winning well over 70% of the time. See which other teams to pick here.

How to make Week 13 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 13 NFL schedule, and it also says a Super Bowl contender goes down hard. It's also backing a shocking team in its NFL survivor picks. You can only get every pick for every game at SportsLine.

So what NFL predictions, NFL pool picks, and NFL survivor picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.

Week 13 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Dec. 4

Steelers at Falcons (+1, 42)

Broncos at Ravens (-8, 38.5)

Packers at Bears (+4.5, 43.5)

Jaguars at Lions (+1, 51.5)

Browns at Texans (+7, 47)

Jets at Vikings (-3, 44.5)

Commanders at Giants  (+2.5, 40.5)

Titans at Eagles (-5, 44.5)

Seahawks at Rams (+7.5, 41)

Dolphins at 49ers (-4, 46.5)