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The home side and their manager, who was subjected to 'sacked in the morning chants' on at least two occasions, will grab most of the headlines. But Newcastle's much-changed roster produced a brilliant performance commensurate with the club's upward trajectory.
Here, Mail Sport takes you through who thrilled on the night and who had an evening to forget in Manchester.
Lewis Hall grabbed his first senior goal with a wonderful volley from the edge of the area
Joe Willock marked his return to the stating line-up with a stunning finish to end United hopes
The defending champions were dumped out of the Carabao Cup on a sorry Old Trafford night
Manchester United (4-2-3-1)
Andre Onana 6
Might have closed the angle on Almiron sooner for the first goal but was largely blameless on the night.
Diogo Dalot 4
Hooked at half-time after a disappointing 45 minutes that saw both Newcastle goals come from down his side. Almiron caused the Portuguese defender all sorts of problems.
Victor Lindelof 5
No glaring mishaps but failed to deal with Gordon's movement on the front line.
Harry Maguire 6
Pretty anonymous for most of the game. Passed the ball well in possession but his header fell to Hall for the Magpies second.
Sergio Reguilon 6
Showed promise very early in the game with some smart link up with Garnacho but faded and was nowhere to be found for the opener as Livramento charged down United's left-flank.
Dalot and Reguilon made up half of United's defence that struggled against Newcastle
Hannibal Mejbri was fortunate not to receive a second yellow card for a foul on Emil Krafth
Hannibal Mejbri 6
Lucky not to have been sent off in the first-half but was the only visible display of passion and aggression from the United team.
Poor return to the starting line-up after injury after he was booked, ran all over and then substituted at the break.
Performed well in flashes but decision-making let him down at crucial moments.
Mason Mount 5
Barely influenced the game in the attacking phases and could do nothing off the ball as the away side dominated the centre of the park.
Alejandro Garnacho 5
Started well but faded. Was another player who showed energy and a bit of spark but did nothing of note after the first 15 minutes.
Mason Mount struggled to influence