Scientists ERASE cocaine-associated memories in rats, in breakthrough for ...

Breakthrough in addiction treatment as scientists ERASE cocaine-associated memories in rats Researchers discovered a way to 'erase' cocaine-associated memories in rats They used optogenetics to tweak neurons that are linked to drug impulses  Findings could be used to develop new drugs or techniques to prevent relapse 

By Cheyenne Macdonald For Dailymail.com

Published: 16:13 GMT, 22 January 2019 | Updated: 18:29 GMT, 22 January 2019

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A new breakthrough in memory research could one day help to prevent recovering addicts from relapsing.

In a study on rats, researchers have identified a way to ‘erase’ cocaine-associated memories to cut down on relapse behavior in the future, even outside of the controlled environment.

The experts say this could make for a much more effective treatment method than current options such as ‘exposure therapy,’ which often falls apart when a patient is out of the therapist’s office and back in the outside world.

Researchers said a region in the brain that plays a key role in forming the memories associated with the rats’ cocaine high and the related cues. The amygdala and the medial geniculate nucleus, which acts like a ‘switchboard for sound,’ were found to be important

Researchers identified a region in a rat's brain that plays a key role in forming the memories associated with the rats’ cocaine high and the related cues. The amygdala and the medial geniculate nucleus, which acts like a ‘switchboard for sound,’ were found to be important

WHAT IS OPTOGENETICS? 

The researchers were able to observe the functions of the rat's brain using a technique called optogenetics. 

Optogenetics targets genetically modified cells in the brain using precise bursts of light.

Using optogenetics, they were able to tweak neurons associated with rats' cocaine-cue memories. 

After erasing these neurons, they found the rats were less likely to engage in drug-seeking behavior, even when they were in a new environment.  

Before optogenetics, scientists had to open the skull and implant electrodes into living tissue to stimulate neurons with electricity and measure their response. 

The researchers used a technique known as optogenetics, in which light pulses are used to control genetically modified cells, to tweak neurons

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