The cavalier King Charles spaniel is the dog breed that carries the most disease-causing genetic mutations, a new study reveals.
The small but adorable breed has been negatively affected by years of inbreeding – putting it at higher risk for heart disease, the study warns.
Specifically, it has genetic variants linked to myxomatous mitral valve disease (MMVD), a common and deadly heart condition.
The past 300 years of dog breeding have created an incredible diversity of breeds with various sizes, shapes and abilities, the authors say.
But unfortunately, this has also caused many breeds to become more inbred and more likely to inherit genetic diseases.
Both King Charles I and his son, Charles II were devotees of the breed. The especially large number of potentially harmful genes in the genomes of cavalier King Charles spaniels, compared to other dogs, likely resulted from its breeding history
Erik Axelsson of Uppsala University in Sweden and colleagues published the new findings today in the journal PLOS Genetics.
'We find that individuals belonging to the breed affected by the most intense breeding – cavalier King Charles spaniel (cKCs) – carry more harmful variants than other breeds,' they say in their paper.
[This indicates] that past breeding practices may have increased the overall levels of harmful genetic variation in dogs.'
The study's researchers wanted to know whether recent breeding practices had increased the number of disease-causing variants in dogs.
They sequenced entire genomes from 20 dogs from eight common breeds, including the beagle, German shepherd, golden retriever and standard poodle.
They found that the cavalier King Charles spaniel, which experienced the most intense breeding, carried more harmful genetic variants than the others.
Standard poodles were also found to carry more harmful mutations than several of the other breeds, but not as many as the cavalier King Charles spaniel.
'We see no significant differences between any pairs involving these six breeds – beagle, German shepherd, golden retriever, Labrador retriever, Rottweiler and West Highland white terrier,' Axelsson told MailOnline.
'They seem to carry approximately similar levels and can't be ordered.'
Next, comparisons of dachshunds with and without signs of heart disease were then used to help identify mutations that potentially predispose cavalier King Charles spaniels to develop MMVD.
Axelsson and colleagues chose to compare dachshunds with cavalier King Charles spaniels, because dachshunds don't develop MMVD very
