Infertility breakthrough as scientists successfully create viable sperm from ...

Infertility breakthrough as scientists successfully create viable sperm from ...
Infertility breakthrough as scientists successfully create viable sperm from ...
Male infertility BREAKTHROUGH as scientists successfully create viable sperm from monkey stem cells – and say it could work on humans too Sperm have been made from monkey stem cells and used to fertilise an egg It is a scientific breakthrough that could lead to human infertility treatments Stem cells taken from a rhesus macaque and converted into primitive sperm Rhesus macaque monkeys share similar reproductive mechanisms to humans

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Sperm have been made from monkey stem cells and used to fertilise a macaque egg in a scientific breakthrough that could lead to human infertility treatments. 

Researchers took some stem cells, converted them into primitive sperm and showed this was capable of fertlising an egg from a rhesus macaque.

The monkeys share similar reproductive mechanisms to humans, making them an 'ideal and necessary model for exploring stem cell-based therapies for male infertility,' experts at the University of Georgia (UGA) said.

It comes fives years after scientists were able to create sperm in a laboratory and use it to father healthy baby mice in another pioneering move.

The hope is that the research could one day pave the way to help men with defects that leave them unable to produce sperm, as well as those whose fertility has been damaged by cancer treatment or infections such as mumps.  

Breakthrough: Sperm have been made from monkey stem cells and used to fertilise a macaque egg in a scientific breakthrough that could lead to human infertility treatments (stock image)

Breakthrough: Sperm have been made from monkey stem cells and used to fertilise a macaque egg in a scientific breakthrough that could lead to human infertility treatments (stock image)

HOW ARE STEM CELLS MADE INTO SPERM?

The scientific breakthrough by experts from the University of Georgia could lead to human infertility treatments.

They managed to make sperm in a lab from monkey stem cells, and used the primitive sperm cells fertilise a macaque egg.

Making sperm in the testes, which takes more than a month from start to finish in most mammals, is one of the longest and most complicated processes in the body.

In the lab, the UGA researchers made functional sperm cells in a dish using primate embryonic stem cells.

These cells can morph into any other type of tissue but are made into immature sperm cells with the help of chemicals, hormones and testicular tissue.

They must also go through a careful rearrangement of their DNA during a process called meiosis, where the sperm cells lose half of their chromosomes so a fertilised egg has a normal amount.

Researchers used embryonic stem cells from rhesus macaque monkeys to generate immature sperm cells known as round spermatids, which do not have a head and a tail for swimming because they're at an earlier stage in their development.

These spermatids were shown to be capable of fertilising a rhesus macaque egg.

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Making sperm in the testes, which takes more than a month from start to finish in most mammals, is one of the longest and most complicated processes in the body. 

The UGA-led study is the

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