The Tory party was in open rebellion against Theresa May tonight as six Cabinet members rebelled against the PM to back a failed Brexiteer amendment and another minister resigned to oppose a no-deal Brexit.
Sarah Newton quit her job at the Department for Work and Pensions in order to defy a last-ditch Government whip and vote against no-deal.
Four Cabinet ministers - David Mundell, Amber Rudd, David Gauke and Greg Clark - and Claire Perry, who attends Cabinet, abstained on the motion, which passed by 321 votes to 278 and makes a Brexit delay likely.
The rebellion for a soft Brexit left Mrs May battling on two fronts after six of her Cabinet ministers backed the hardliners' so-called Malthouse compromise.
As Tory leadership rivals jockeyed for position, Foreign Secretary Jeremy Hunt and Home Secretary Sajid Javid were among 164 MPs who voted in favour of the failed Brexiteer plan.
Defence Secretary Gavin Williamson also backed the Brexiteer amendment, as did Commons Leader Andrea Leadsom, who challenged Mrs May for the leadership in 2016.
Nicky Morgan, the former education secretary, said senior ministers and other top Tory figures needed to have a 'conversation' about Mrs May's future if sh lost a strong of Brexit votes this week
The Malthouse amendment, which would allow a no-deal Brexit but delay it until May, was heavily defeated in the Commons.
But the support from high-profile ministers will undoubtedly do their leadership credentials no harm among the party rank and file.
Including parliamentary private secretaries, who are expected to vote for the Government, there were 17 rebels on the final no-deal vote.
Fifteen including Miss Rudd abstained, while two - Ms Newton and Paul Masterson - voted against the Government.
Cabinet ministers were earlier urged to tell Mrs May to step down if she loses more votes this week.
Nicky Morgan, the former education secretary, said senior ministers and other top Tories should have a 'conversation' about her future if this week goes catastrophically wrong.
Ms Morgan, a Remainer who has in recent weeks seemed to ally herself with hardcore Brexiteers to help generate the Malthouse Compromise plan for a managed no-deal Brexit, spoke against the Prime Minister on Newsnight.
The Loughborough MP said: 'I think her position is going to be very difficult if after the end of this week she has lost tonight and then the votes later on in the week go against her.
'It will be up to the Cabinet to have that conversation. You have to do it as a collective, the Cabinet have to be working together on that.
'The chief whip, the chair of the 1922 committee … If I was in Cabinet, I would be having those conversations.'
Meanwhile Chancellor Philip Hammond appeared to go off-script during his Spring
