The quarterback appeared at the Bank of America Stadium in a headscarf and shades - a look which Twitter users were quick to point out was made famous by Susan Sarandon's character in 'Thelma and Louise'.
Newton arrived kept the scarf - paired with fancy, dark suit - for the post-game press conference.
And those who saw Newton's fashion statement were relentless.
Carolina Panthers quarterback Cam Newton lights up Twitter for his choice of head wear
Drawing comparison: Many on Twitter made the connection to Susan Sarandon after Panther QB Cam Newton stepped out in a scarf Thursday
Many on Twitter compare Cam Newton's scarf to Thelma and Louise (above parodied in Wayne's World)
One Twitter user joked: 'Cam Newton going with the Thelma and Louise ending to the Panthers season.'
If you're not familiar with the movie, the female bank robbers get away from police by driving into a canyon and likely killing themselves.
Not everyone on social media went for the Thelma and Louise reference.
Others posted images comparing Newton to Britain's Queen Elizabeth, Stephen Spielberg's alien ET, and Zoolander character Mugatu, platyed by Will Ferrell.
And another posted a picture of their dog wearing a similar scarf, and accused Newton of stealing her look.
Social media users compared Newton's look to headscarfs worn by Queen Elizabeth
The star was compared to Steven Spielberg's alien creation ET
One user posted a picture of her dog in a similar scarf, and accused Cm of stealing her look
Another Twitter user compared the look to Will Ferrell's