But even the most nervous of fliers should take heart when flying Australia's flag carrier, Qantas -- as it has just been rated the safest airline in the world for what is effectively the seventh year in a row.
But this year, Qantas has returned to the top.
The rankings take into account factors including audits from aviation bodies and governments, crash and serious incident records, fleet age, financial position, pilot training and culture.
They did not look at minor incidents, as "all airlines have incidents every day," says Geoffrey Thomas, editor-in-chief of the Australian-based website.
"It is the way the flight crew handles incidents that determines a good airline from an unsafe one," he tells CNN Travel.
"Qantas has been the lead airline in virtually every major operational safety advancement over the past 60 years and has not had a fatality in the pure-jet era."
The runners up
Air New Zealand comes in second, while Taiwan's EVA Air is third. Abu Dhabi-based Etihad Airways -- a new entry -- ranks fourth.
The rest of the top 10 is made up of Qatar Airways, Singapore Airlines, Emirates, Alaska Airlines, Cathay Pacific and Virgin Australia.
Ranked 10-20 are Hawaiian Airlines, Virgin Atlantic, TAP Air Portugal, SAS, Royal Jordanian, Swiss, Finnair, Lufthansa, Aer Lingus and KLM.
Notable exceptions from the list are British Airways, ANA, American Airlines and United, all of which made the top 20 last year. Japan Airlines and Delta also failed to make the cut -- both have been on previous lists.
Thomas says British Airways slid down the rankings due to a "combination of fleet age [average 13.8 years] and the number of incidents... which were not life-threatening but there were a lot of them compared to other airlines of similar size."
Thomas praises Qantas's innovations, including the "extraordinary success of its Perth to London Boeing 787 nonstop service" and its recent London-Sydney and New York-Sydney test flights.
He also notes there was "not much between the top 10" airlines, but that "wider gaps appear from 10 to 20."
The website has also produced a list of the world's safest budget airlines, although these are ranked equally, and so listed alphabetically. They are: Air Arabia, Flybe, Frontier, HK Express, IndiGo, Jetblue, Volaris, Vueling, Westjet and Wizz Air.
World's safest airlines
2: Air New Zealand
3: EVA Airsonos sonos One (Gen 2) - Voice Controlled Smart Speaker with Amazon Alexa Built-in - Black read more
4: Etihad Airways
5: Qatar Airways
6: Singapore Airlines
8: Alaska Airlines
9: Cathay Pacific
10: Virgin Australia
11: Hawaiian Airlines
12: Virgin Atlantic
13: TAP Air Portugal
15: Royal Jordanian
19: Aer Lingus