Victoria is set to report 725 new cases of coronavirus, its highest total ever.
The figure is worse than the previous record of 723 new cases on Thursday.
A victim in their 30s has reportedly become Australia's youngest person to die from the disease.
Melbourne has been in stage-four lockdown since Sunday with schools shut, weddings banned, and citizens restricted to within a 5km radius of their homes.
Between 8pm and 5am, residents are only allowed to leave their house for work and essential health, care or safety reasons.
Thousands of businesses including pubs and shops have been ordered to close from 11.59pm on Wednesday, putting 250,000 people out of work.
Victoria is set to report 725 new cases of coronavirus. Pictured: A cyclist in Albert Park, Melbourne on Wednesday
A Coles store in Melbourne is left with empty shelves as residents stocked up during stage-four lockdown
At the same time, stage three restrictions that allow people to only leave home for work, exercise, care and essential shopping will be introduced across Victoria.
On Tuesday night, Premier Daniel Andrews tweeted three photos showing the city's normally bustling streets empty, and thanked Victorians for sticking to the rules.
The premier shared seven photos across two posts - including those showing the Tullamarine Freeway and the M80 Ring Road.
Both are normally filled with traffic and act as major arteries going in and around central Melbourne.
In the caption, Mr Andrews wrote simply: 'Thank you.'
In the caption to the tweet separated into two posts, Mr Andrews wrote simply: 'Thank you'
A woman wearing a face mask is pictured crossing the road as a large group of police patrol the streets in Melbourne on Tuesday
It comes as federal Education Minister Dan Tehan unveils a rescue package for childcare in the state.
Parents will be given an extra 30 days of allowable absences so they can keep their children enrolled even if they cannot send them to care.
Prime Minister Scott Morrison said the initiative would secure childcare spots, while ensuring no centres closed or jobs were lost.
'A triple guarantee for parents, the services themselves, as well as for the employees,' he told the Seven Network.
'This is necessitated by this big lockdown in Melbourne.'
Childcare centres will continue to receive government subsidies to remain open and keep staff employed during the six-week lockdown.
Police and soldiers speak to locals as they patrol the Dockland areas of Melbourne on Sunday
Pictured: Victorians lining up at supermarkets to buy meat and fish as shortages are expected
Melburnians will now be made to carry a work permit signed by their employer (pictured police officers patrol running track in Melbourne on Tuesday)
Victoria recorded 725 cases on Wednesday
Victoria recorded 439 new cases on Tuesday and another 11 deaths, bringing the national toll to 232.
All the deaths recorded in Victoria are linked to aged care.
Mr Morrison said there had been unacceptable outcomes in the most severely affected homes.
'There's over 430 aged care facilities in Melbourne and what we've had is some horrible outcomes in a couple,' he said.
'There's been about half a dozen that have been in an acute sense but the balance, even those with COVID cases, have been managing very well.'
Victorians who have used up all their sick leave can get $1,500 from the federal government if they have to self-isolate for two weeks.
The pandemic leave will also be on offer in other states that declare a state of emergency.
Unions and Labor have been pushing for a national scheme, stressing the need to prevent outbreaks triggered by workplace transmission.
'That option is there for other states and territories where they believe they need to move to that stage,'