On Saturday afternoon, Trump named Amy Coney Barrett, 48, of the Chicago-based 7th Circuit and Barbara Lagoa, 52, of the Atlanta-based 11th Circuit as possible nominees.
Emerging as the favorite is Barrett, 48, a mother of seven children, including two adopted from Haiti and one with special needs.
Her involvement in a cult-like Catholic group where members are assigned a 'handmaiden' has caused concern in Barret's nomination to other courts and is set to come under fierce review again if she is Trump's pick.
The group was the one which helped inspire 'The Handmaids Tale', book's author Margaret Atwood has said.
Barrett emerges now as a front runner after she was already shortlisted for the nomination in 2018 which eventually went to Brett Kavanaugh.
Trump called the federal appellate court judge 'very highly respected' when questioned about her Saturday.
Born in New Orleans in 1972, she was the first and only woman to occupy an Indiana seat on the Seventh Circuit Court of Appeals.
Married to Jesse M. Barrett, a partner at SouthBank Legal in South Bend and former Assistant United States Attorney for the Northern District of Indiana, the couple have five biological and two adopted children.
Their youngest biological child has Down Syndrome.
Friends say she is a devoted mother - and say with just an hour to go until she was voted into the 7th District Court of Appeals by the U.S. Senate in 2017, Barrett was outside trick-or-treating with her kids.
Barrett's strong Christian ideology makes her a favorite of the right but her involvement in a religious group sometimes branded as a 'cult' is set to be harshly criticized.
In 2017, her affiliation to the small, tightly knit Christian group called People of Praise caused concern while she was a nominee for a seat on the United States Court of Appeals for the Seventh Circuit.
The New York Times reported that the practices of the group would surprise even other Catholics with members of the group swearing a lifelong oath of loyalty, called a covenant, to one another.
They are also assigned and held accountable to a personal adviser, known until recently as a 'head' for men and a 'handmaid' for women and believe in prophecy, speaking in tongues and divine healings.
Members are also encouraged to confess personal sins, financial information and other sensitive disclosures to these advisors.
Advisors are allowed to report these admissions to group leadership if necessary, according to an account of one former member.
The organization itself says that the term 'handmaid' was a reference to Jesus's mother Mary's description of herself as a 'handmaid of the Lord.'
They said they recently stopped using the term due to cultural shifts and now use the name 'women leaders.'
The group deems that husbands are the heads of their wives and should take authority over the family while 'the heads and handmaids give direction on important decisions, including whom to date or marry, where to live, whether to take a job or buy a home, and how to raise children,' the Times reported.
Unmarried members are placed living with married couples members often look to buy or rent homes near other members.
Founded in 1971, People of Praise was part of the era's 'great emergence of lay ministries and lay movements in the Catholic Church,' founder Bishop Peter Smith told the Catholic News Agency.
Beginning with just 29 members, it now has an estimated 2,000.
According to CNA, some former members of the People of Praise allege that leaders exerted undue influence over family decision-making, or pressured the children of members to commit to the group.
At least 10 members of Barrett's family, not including their children, also belong to the group.
Barrett's father, Mike Coney, serves on the People of Praise's powerful 11-member board of governors, described as the group's 'highest authority.'
Her mother Linda served as a handmaiden.
The group's ultra-conservative religious tenets helped spur author Margaret