Dan Andrews' Labor government is in crisis with as many as 10 ministers set to be pushed out of power as part of an ongoing factional purge.
According to reports by The Age, MPs linked to disgraced former Labor powerbroker Adam Somyurek feel abandoned by the Victorian premier and are facing preselection challenges before next year's elections.
Mr Andrews sparked further anger after promoting Anthony Carbines to his cabinet on Monday, with anonymous sources telling the publication the Labor leader had 'humiliated' his members and the party is now 'spiralling out of control'.
'This is a real threat. It'll be by-election after by-election after by-election,' a senior MP said.
'This will bring the government's agenda undone if the madness won't stop. Two or three people, maybe people can swallow that, but not this many. It's madness.'
Dan Andrew's Labor government is in crisis with as many as 10 ministers set to be pushed out of power as part of an ongoing factional purge
There have been calls for Mr Andrews to meet with ministers concerned about their positions, but his refusal to do so has caused further anger among the party.
Among those in the firing line include Broadmeadows' Frank McGuire, Kororoit's Marlene Kairouz and Luke Donnellan, who stepped down from the cabinet after investigations into the minister paying for people's Labor memberships.
There are another five positions in the upper and lower houses that are at risk of by-elections - all of whom are linked Mr Somyurek, who was forced out of the Labor party after alleged branch-stacking.
The premier could be forced for a massive reshuffling of his team and has been criticised for taking his annual leave a week earlier this year.
Mr Andrews is set to go on holiday from Friday, which one anonymous MP said could have huge ramifications for next year's election.
'The emperor is leaving as Rome is burning,' they told The Age.
Mr Andrews' pandemic bill sparked riotous protests across Melbourne but will now take effect on December 16 after it passed the upper house by a thin margin of 20 votes to 18
Even Mr Andrews' most loyal 'socialist left' supporters apparently have grown tired of his 'bloodthirsty' leadership approach.
'These things can lose you government,' a minister told The Age.
'If you get enough people with sh*t on their livers for the next year and just pour out bile, that's a lot of bile.'
Labor officials are quietly concerned disgruntled upper house MPs could actively sabotage the party's policies in revolt against Mr Andrews.
Among those in the firing line is Kororoit's Marlene Kairouz, who said she would quit politics if she lost preselection
On Monday MP Mark Gepp plunged Mr Andrews' government into deeper crisis after he became the sixth Labor MP in just a matter of days to reveal he's quitting.
Mr Gepp joins Lara MP John Eren, Richmond MP Richard Wynne, Altona MP Jill Hennessy, Ringwood MP Dustin Halse and Yan Yean MP Danielle Green who all announced last week that they would not be seeking re-election in 2022.
On Thursday, the Victorian premier had to rely on the support of crossbenchers to get his controversial pandemic bill through parliament after a 21-hour debate.
The bill sparked riotous protests across Melbourne but will now take effect on December 16 after it passed the upper house by a thin margin of 20 votes to 18.
The Victorian Labor Party has been thrown into disarray after five parliamentarians threw in the towel last week (pictured, Premier Daniel Andrews alongside local ministers)
Transport Matters MP Rod Barton, Animal Justice Party MP Andy Meddick, Reason Party MP Fiona Patten and Greens leader Samantha Ratnam voted with the government to make the Public Health and Wellbeing Amendment (Pandemic Management) Bill law.
The bill gives the premier and health minister - rather than the chief health officer - the power to declare a pandemic.
They will also enforce restrictions during a health crisis when Victoria's state of emergency laws expire in two weeks.
The legislation became a lightning rod for anti-lockdown and anti-vaccination groups, who have occupied the steps of state parliament for weeks in protest.
Protesters slammed the proposed bill as 'dangerous legislation' that they say gives premier Dan Andrews too much power.
With strong opposition to the legislation, Mr Andrews made a raft of last minute changes in order to win over key crossbench MPs and push it through parliament.
Under the new bill, the premier can declare a health emergency and lockdown the state in three-month blocks for as long as he likes.
The original legislation would also have seen a range of even more unprecedented powers handed to the premier and health