It's believed the film only had two weeks of shooting remaining when writer/director Ol Parker made the call for production to be paused for at least three months.
Some of those who contracted the virus worked in close proximity with Mr Clooney and Ms Roberts.
Julia Roberts (left and George Clooney) are understood to have returned to the US after production was paused on their romantic comedy, Ticket To Paradise, being filmed in Queensland, due to the latest Covid outbreak
George Clooney (in lemon shirt) is seen on the Gold Coast during production of his rom-com with Julia Roberts, Ticket To Paradise
One source said Mr Clooney had shaved off the beard he had grown for the role before departing Australia on a flight bound for Honolulu, where he connected with another flight back to California.
A couple of the film's key international production staff have remained in Queensland for two more weeks.
Ironically production of the film, which is set in Bali, was moved to Australia because of fears about the number of Covid cases in Indonesia.
Arts Minister Paul Fletcher announced in March last year that Ticket To Paradise would film in Queensland locations including the Whitsundays, Brisbane and the Gold Coast.
In support of the film, produced by UK film-maker Working Title Films, Universal Pictures, Clooney's Smokehouse Pictures and Roberts's Red Om Films, the Federal government provided a $6.4 million grant.
Mr Fletcher said the movie would generate at least 270 jobs and inject $47 million into the local economy.
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