'I think you have to be honest that you can be a foggy, meandering president. Say, like Reagan near the end, if you're winning,' Jones said during the evening newscast.
'But if you are foggy and meandering on key questions and you're also not winning, then you've got a real problem.'
Biden has been criticized over his cognitive health since he first started his presidential campaign.
Similarly, Reagan - whose memory and cognitive function were impacted by Alzheimer's towards the end of his life - was scrutinized by the public as some speculated he was battling the early stages of the disease in the late 1980s while he was still serving as president.
CNN host Van Jones said Joe Biden (left) was 'foggy' and 'meandering' during his Wednesday press conference and compared him to an Alzheimer's suffering Ronald Reagan (right)
The broadcaster's commentary addressed Biden's earlier exchange with a reporter who asked him if he was 'satisfied' with Vice President Kamala Harris' work on voting rights and if he was committing to having her as his running mate in 2024.
Biden answered: 'Yes and yes.'
Apparently shocked by his reply, the reporter questioned: 'Do you care to expand?'