The crash happened near a bridge on the main road outside of Pietermaritzburg, in South Africa's KwaZulu-Natal province, according to authorities.
The Department of Transport said the minibus was overloaded -- carrying 10 more people than its license allowed. Twenty-six people were on board, including the driver.
ER24 reported that local residents had taken as many as 12 injured victims from the minibus to a nearby clinic. The injured were later transferred to hospitals.
Authorities have not released the cause of the crash.
CNN's Sarah Faidell contributed to this report.